Sex-specific association of blood triglyceride and uric acid with body shapes in Chinese adults
Background: Abnormal metabolic syndrome, adipose distribution and different body shapes caused by obesity are associated with the levels of blood biochemical indexes. However, the sex-specific relationship between body shapes and blood biochemical indexes is poorly investigated. Research design and...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Human Nutrition & Metabolism |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666149724000598 |
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| author | Xixiang Wang Jingjing Xu Yiyao Gu Jie Mu Shaobo Zhou Xiaojun Ma Lu Liu Yu Liu Zhi Duan Linhong Yuan Ying Wang |
| author_facet | Xixiang Wang Jingjing Xu Yiyao Gu Jie Mu Shaobo Zhou Xiaojun Ma Lu Liu Yu Liu Zhi Duan Linhong Yuan Ying Wang |
| author_sort | Xixiang Wang |
| collection | DOAJ |
| description | Background: Abnormal metabolic syndrome, adipose distribution and different body shapes caused by obesity are associated with the levels of blood biochemical indexes. However, the sex-specific relationship between body shapes and blood biochemical indexes is poorly investigated. Research design and methods: A cross-sectional study was conducted on 1828 subjects matched by age and sex. The scatter plot and restricted cubic spline were used to analyze the correlation between variables. Logistic regression was used to explore the relationship between body shapes and the risk of abnormal blood biochemical indexes level. Results: Compared with the non-obesity group, the compound obesity group had a higher risk of abnormal Glu and TG levels independent of sex. Besides, the sex-specific association showed that the risk of abnormal TG levels was higher in males with peripheral obesity but in females with central obesity. Meanwhile, female subjects with peripheral obesity had a higher risk of abnormal UA levels. Conclusions: This study showed that obese subjects had a higher risk of abnormal UA and TG compared to non-obese subjects, and there were sex differences in this relationship, suggesting that future studies exploring the relationship between body shapes and blood biochemical indexes also need to consider the potential role of sex. |
| format | Article |
| id | doaj-art-52b7ad0fabd74c48a8bdc3bc499b0d2b |
| institution | Kabale University |
| issn | 2666-1497 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Human Nutrition & Metabolism |
| spelling | doaj-art-52b7ad0fabd74c48a8bdc3bc499b0d2b2025-02-06T05:12:48ZengElsevierHuman Nutrition & Metabolism2666-14972025-03-0139200297Sex-specific association of blood triglyceride and uric acid with body shapes in Chinese adultsXixiang Wang0Jingjing Xu1Yiyao Gu2Jie Mu3Shaobo Zhou4Xiaojun Ma5Lu Liu6Yu Liu7Zhi Duan8Linhong Yuan9Ying Wang10School of Public Health, Capital Medical University, Beijing, 100069, PR ChinaSchool of Public Health, Capital Medical University, Beijing, 100069, PR ChinaSuzhou Research Center of Medical School, Suzhou Hospital, Afffliated Hospital of Medical School, Nanjing University, Suzhou, PR ChinaSuzhou Research Center of Medical School, Suzhou Hospital, Afffliated Hospital of Medical School, Nanjing University, Suzhou, PR ChinaSchool of Science, Faculty of Engineering and Science, University of Greenwich, Central Avenue, Chatham, ME4 4TB, UKSchool of Public Health, Capital Medical University, Beijing, 100069, PR ChinaSchool of Public Health, Capital Medical University, Beijing, 100069, PR ChinaSchool of Public Health, Capital Medical University, Beijing, 100069, PR ChinaSuzhou Research Center of Medical School, Suzhou Hospital, Afffliated Hospital of Medical School, Nanjing University, Suzhou, PR ChinaSchool of Public Health, Capital Medical University, Beijing, 100069, PR China; Corresponding author.Suzhou Research Center of Medical School, Suzhou Hospital, Afffliated Hospital of Medical School, Nanjing University, Suzhou, PR China; Corresponding author.Background: Abnormal metabolic syndrome, adipose distribution and different body shapes caused by obesity are associated with the levels of blood biochemical indexes. However, the sex-specific relationship between body shapes and blood biochemical indexes is poorly investigated. Research design and methods: A cross-sectional study was conducted on 1828 subjects matched by age and sex. The scatter plot and restricted cubic spline were used to analyze the correlation between variables. Logistic regression was used to explore the relationship between body shapes and the risk of abnormal blood biochemical indexes level. Results: Compared with the non-obesity group, the compound obesity group had a higher risk of abnormal Glu and TG levels independent of sex. Besides, the sex-specific association showed that the risk of abnormal TG levels was higher in males with peripheral obesity but in females with central obesity. Meanwhile, female subjects with peripheral obesity had a higher risk of abnormal UA levels. Conclusions: This study showed that obese subjects had a higher risk of abnormal UA and TG compared to non-obese subjects, and there were sex differences in this relationship, suggesting that future studies exploring the relationship between body shapes and blood biochemical indexes also need to consider the potential role of sex.http://www.sciencedirect.com/science/article/pii/S2666149724000598ObesityAdipose distributionBlood biochemical indexCross-sectional studySex difference |
| spellingShingle | Xixiang Wang Jingjing Xu Yiyao Gu Jie Mu Shaobo Zhou Xiaojun Ma Lu Liu Yu Liu Zhi Duan Linhong Yuan Ying Wang Sex-specific association of blood triglyceride and uric acid with body shapes in Chinese adults Human Nutrition & Metabolism Obesity Adipose distribution Blood biochemical index Cross-sectional study Sex difference |
| title | Sex-specific association of blood triglyceride and uric acid with body shapes in Chinese adults |
| title_full | Sex-specific association of blood triglyceride and uric acid with body shapes in Chinese adults |
| title_fullStr | Sex-specific association of blood triglyceride and uric acid with body shapes in Chinese adults |
| title_full_unstemmed | Sex-specific association of blood triglyceride and uric acid with body shapes in Chinese adults |
| title_short | Sex-specific association of blood triglyceride and uric acid with body shapes in Chinese adults |
| title_sort | sex specific association of blood triglyceride and uric acid with body shapes in chinese adults |
| topic | Obesity Adipose distribution Blood biochemical index Cross-sectional study Sex difference |
| url | http://www.sciencedirect.com/science/article/pii/S2666149724000598 |
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