Development of a Cationic Polymeric Micellar Structure with Endosomal Escape Capability Enables Enhanced Intramuscular Transfection of mRNA-LNPs

Development of a Cationic Polymeric Micellar Structure with Endosomal Escape Capability Enables Enhanced Intramuscular Transfection of mRNA-LNPs

<b>Background/Objectives:</b> The endosomal escape of lipid nanoparticles (LNPs) is crucial for efficient mRNA-based therapeutics. Here, we present a cationic polymeric micelle (cPM) as a safe and potent co-delivery system with enhanced endosomal escape capabilities. <b>Methods:<...

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Bibliographic Details
Main Authors: Siyuan Deng, Han Shao, Hongtao Shang, Lingjin Pang, Xiaomeng Chen, Jingyi Cao, Yi Wang, Zhao Zhao
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Vaccines
Subjects:
mRNA-LNP
cationic polymeric micelle
endosomal escape
transfection efficiency
Online Access:https://www.mdpi.com/2076-393X/13/1/25
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