Screening helper T lymphocyte epitopes based on IFN-γ/IL-10 ratio for developing a novel multi-epitope vaccine candidate using Wolbachia surface protein as an adjuvant against visceral leishmaniasis

Screening helper T lymphocyte epitopes based on IFN-γ/IL-10 ratio for developing a novel multi-epitope vaccine candidate using Wolbachia surface protein as an adjuvant against visceral leishmaniasis

Abstract Background Visceral leishmaniasis (VL) is the most lethal form of leishmaniasis. In terms of anti-leishmanial vaccines, favorable immune responses are Th1 responses that primarily produce interferon gamma (IFN-γ) and activate macrophages for leishmanicidal effects. The selection of IFN-γ-in...

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Main Authors: Jianhui Zhang, Tianhang Lv, Shuoyan Tan, Lingqi Yu, Yangjian Chi, Jianping Chen, Xiaohui Fan, Xiaoyan Lu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Parasites & Vectors
Subjects:
Leishmania
Multi-epitope vaccine
Immunoinformatics
Wolbachia surface protein
Adjuvant
Online Access:https://doi.org/10.1186/s13071-025-06756-5
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https://doi.org/10.1186/s13071-025-06756-5

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