Modulating cytokine microenvironment during T cell activation induces protective RSV-specific lung resident memory T cells in early life in mice

Abstract Maternal immunisation against respiratory viruses provides protection in early life, but as antibodies wane, there can be a gap in coverage. This immunity gap might be filled by inducing pathogen-specific lung tissue-resident T cells (TRM). However, the neonatal mouse lung has a different i...

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Bibliographic Details
Main Authors: Ziyin Wang, Miko Zhong, Chubicka Thomas, Ekaterina Kinnear, Tom Rice, Beth Holder, Beate Kampmann, John S. Tregoning
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:npj Viruses
Online Access:https://doi.org/10.1038/s44298-024-00073-x
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