Identification and characterization of tumor and stromal derived liquid biopsy analytes in pancreatic ductal adenocarcinoma

Identification and characterization of tumor and stromal derived liquid biopsy analytes in pancreatic ductal adenocarcinoma

Abstract Background The lack of predictive biomarkers contributes notably to the poor outcomes of patients with pancreatic ductal adenocarcinoma (PDAC). Cancer-associated fibroblasts (CAFs) are the key components of the prominent PDAC stroma. Data on clinical relevance of CAFs entering the bloodstre...

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Main Authors: Julian Götze, Kira Meißner, Thais Pereira-Veiga, Yassine Belloum, Svenja Schneegans, Jolanthe Kropidlowski, Joao Gorgulho, Alina Busch, Kim Christin Honselmann, Martin Schönrock, Arne Putscher, Sven Peine, Christine Nitschke, Ronald Simon, Volker Spindler, Jakob Robert Izbicki, Thilo Hackert, Carsten Bokemeyer, Klaus Pantel, Faik Güntaç Uzunoglu, Marianne Sinn, Harriet Wikman
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
PDAC
CCAFs
Liquid biopsy
Stroma
Hyaluronan
Online Access:https://doi.org/10.1186/s13046-024-03262-x
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https://doi.org/10.1186/s13046-024-03262-x

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