A CRISPR/Cas9-based enhancement of high-throughput single-cell transcriptomics

A CRISPR/Cas9-based enhancement of high-throughput single-cell transcriptomics

Abstract Single-cell RNA-seq (scRNAseq) struggles to capture the cellular heterogeneity of transcripts within individual cells due to the prevalence of highly abundant and ubiquitous transcripts, which can obscure the detection of biologically distinct transcripts expressed up to several orders of m...

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Main Authors: Amitabh C. Pandey, Jon Bezney, Dante DeAscanis, Ethan B. Kirsch, Farin Ahmed, Austin Crinklaw, Kumari Sonal Choudhary, Tony Mandala, Jeffrey Deason, Jasmin S. Hamidi, Azeem Siddique, Sridhar Ranganathan, Keith Brown, Jon Armstrong, Steven Head, Phillip Ordoukhanian, Lars M. Steinmetz, Eric J. Topol
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59880-2
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