Epigenetic silencing and CRISPR-mediated reactivation of tight junction protein claudin10b (CLDN10B) in renal cancer

Epigenetic silencing and CRISPR-mediated reactivation of tight junction protein claudin10b (CLDN10B) in renal cancer

Abstract Background The kidney’s tubular system relies on cell polarity and tight junctions to maintain structure and function and disruptions contribute to diseases like cancer. Loss of tight junction proteins such as Claudins can actively contribute to tumorigenesis. Results We aimed to identify b...

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Main Authors: Sarah Arroyo Villora, Yufen Zhao, Paula Castellanos Silva, Alba A. Hahn, Vivien Olanin, David Groll, Sandra Maurer, Vera Roetzer, Witold Szymanski, Tara Procida-Kowalski, Niklas Philipp, Aline Koch, Marek Bartkuhn, Johannes Graumann, Richard Volckmann, Jan Koster, Oliver Rossbach, Denise Salzig, Reinhard Dammann, Cornelia Sigges, Jan Halbritter, Silke Haerteis, Antje Maria Richter
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Clinical Epigenetics
Subjects:
CLDN10
Renal cell carcinoma (RCC)
DNA (hyper)methylation
Epigenetic editing
CRISPR-Cas9
Tumor suppressor
Online Access:https://doi.org/10.1186/s13148-025-01911-2
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https://doi.org/10.1186/s13148-025-01911-2

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