PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid Granulomatosis
Posttransplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of solid organ transplantation. The majority of PTLD is of B-cell origin, and 90% are associated with the Epstein-Barr virus (EBV). Lymphomatoid granulomatosis (LG) is a rare, EBV-associated systemic angiodestruct...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/239719 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559071051382784 |
|---|---|
| author | A. Stravodimou A. Cairoli T. Rausch R. Du Pasquier P. Michel |
| author_facet | A. Stravodimou A. Cairoli T. Rausch R. Du Pasquier P. Michel |
| author_sort | A. Stravodimou |
| collection | DOAJ |
| description | Posttransplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of solid organ transplantation. The majority of PTLD is of B-cell origin, and 90% are associated with the Epstein-Barr virus (EBV). Lymphomatoid granulomatosis (LG) is a rare, EBV-associated systemic angiodestructive lymphoproliferative disorder, which has rarely been described in patients with renal transplantation. We report the case of a patient with renal transplantation for SLE, who presented, 9 months after renal transplantation, an EBV-associated LG limited to the intracranial structures that recovered completely after adjustment of her immunosuppressive treatment. Nine years later, she developed a second PTLD disorder with central nervous system initial manifestation. Workup revealed an EBV-positive PTLD Burkitt lymphoma, widely disseminated in most organs. In summary, the reported patient presented two lymphoproliferative disorders (LG and Burkitt's lymphoma), both with initial neurological manifestation, at 9 years interval. With careful reduction of the immunosuppression after the first manifestation and with the use of chemotherapy combined with radiotherapy after the second manifestation, our patient showed complete disappearance of neurologic symptoms and she is clinically well with good kidney function. No recurrence has been observed by radiological imaging until now. |
| format | Article |
| id | doaj-art-51a6852af0054654a20298b67cfd93f6 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-51a6852af0054654a20298b67cfd93f62025-02-03T01:30:49ZengWileyCase Reports in Medicine1687-96271687-96352012-01-01201210.1155/2012/239719239719PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid GranulomatosisA. Stravodimou0A. Cairoli1T. Rausch2R. Du Pasquier3P. Michel4Department of Oncology, University Hospital of Lausanne, Rue du Bugnon 21, 1011 Lausanne, SwitzerlandHaematology Service, University Hospital of Lausanne, Rue du Bugnon 21, 1011 Lausanne, SwitzerlandInstitute of Pathology, University Hospital of Lausanne, Rue du Bugnon 21, 1011 Lausanne, SwitzerlandNeurology Service, University Hospital of Lausanne, Rue du Bugnon 21, 1011 Lausanne, SwitzerlandNeurology Service, University Hospital of Lausanne, Rue du Bugnon 21, 1011 Lausanne, SwitzerlandPosttransplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of solid organ transplantation. The majority of PTLD is of B-cell origin, and 90% are associated with the Epstein-Barr virus (EBV). Lymphomatoid granulomatosis (LG) is a rare, EBV-associated systemic angiodestructive lymphoproliferative disorder, which has rarely been described in patients with renal transplantation. We report the case of a patient with renal transplantation for SLE, who presented, 9 months after renal transplantation, an EBV-associated LG limited to the intracranial structures that recovered completely after adjustment of her immunosuppressive treatment. Nine years later, she developed a second PTLD disorder with central nervous system initial manifestation. Workup revealed an EBV-positive PTLD Burkitt lymphoma, widely disseminated in most organs. In summary, the reported patient presented two lymphoproliferative disorders (LG and Burkitt's lymphoma), both with initial neurological manifestation, at 9 years interval. With careful reduction of the immunosuppression after the first manifestation and with the use of chemotherapy combined with radiotherapy after the second manifestation, our patient showed complete disappearance of neurologic symptoms and she is clinically well with good kidney function. No recurrence has been observed by radiological imaging until now.http://dx.doi.org/10.1155/2012/239719 |
| spellingShingle | A. Stravodimou A. Cairoli T. Rausch R. Du Pasquier P. Michel PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid Granulomatosis Case Reports in Medicine |
| title | PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid Granulomatosis |
| title_full | PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid Granulomatosis |
| title_fullStr | PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid Granulomatosis |
| title_full_unstemmed | PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid Granulomatosis |
| title_short | PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid Granulomatosis |
| title_sort | ptld burkitt lymphoma in a patient with remote lymphomatoid granulomatosis |
| url | http://dx.doi.org/10.1155/2012/239719 |
| work_keys_str_mv | AT astravodimou ptldburkittlymphomainapatientwithremotelymphomatoidgranulomatosis AT acairoli ptldburkittlymphomainapatientwithremotelymphomatoidgranulomatosis AT trausch ptldburkittlymphomainapatientwithremotelymphomatoidgranulomatosis AT rdupasquier ptldburkittlymphomainapatientwithremotelymphomatoidgranulomatosis AT pmichel ptldburkittlymphomainapatientwithremotelymphomatoidgranulomatosis |