Current methods of studying of the proliferative activity in experiment
Aims. To analyze the contemporary scientifi c literature data about methods of determining of the proliferative activity, as well as the choice of an optimal method for its assessing in tissues with expected low proliferative activity. Methods and results. This is necessary to select an optimal me...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Zaporizhzhia State Medical and Pharmaceutical University
2014-04-01
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| Series: | Patologìâ |
| Subjects: | |
| Online Access: | http://pat.zsmu.edu.ua/article/view/25201/22627 |
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| Summary: | Aims. To analyze the contemporary scientifi c literature data about methods of determining of the proliferative activity, as well as the
choice of an optimal method for its assessing in tissues with expected low proliferative activity.
Methods and results. This is necessary to select an optimal method for assessing of the proliferative activity in tissues with expected
low proliferative activity. The article gives a detailed analysis of the current literature, describes various methods of studying of the
proliferative activity of tissues in experiment.
Conclusion. Bromodeoxyuridine is a versatile and highly effective marker of DNA replication and cell proliferation, allowing carrying
out a dynamic observation of the experiment, including tissues with expected low proliferative activity. It can be widely used
in chronic experiments on small rodents, in the simulation of various pathologies and studying the effect of pharmaceuticals on the activity of proliferation. |
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| ISSN: | 2306-8027 2310-1237 |