Effects of Orally Administered Lactoferrin and Lactoperoxidase-Containing Tablets on Clinical and Bacteriological Profiles in Chronic Periodontitis Patients
This study was undertaken to evaluate the effect of oral administration of lactoferrin (LF) and lactoperoxidase-(LPO-)containing tablet on periodontal condition. Seventy-two individuals with chronic periodontitis were randomly assigned to take either bovine LF and LPO-containing tablets (test group,...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2011/405139 |
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| author | Eiju Shimizu Tetsuo Kobayashi Hiroyuki Wakabayashi Koji Yamauchi Keiji Iwatsuki Hiromasa Yoshie |
| author_facet | Eiju Shimizu Tetsuo Kobayashi Hiroyuki Wakabayashi Koji Yamauchi Keiji Iwatsuki Hiromasa Yoshie |
| author_sort | Eiju Shimizu |
| collection | DOAJ |
| description | This study was undertaken to evaluate the effect of oral administration of lactoferrin (LF) and lactoperoxidase-(LPO-)containing tablet on periodontal condition. Seventy-two individuals with chronic periodontitis were randomly assigned to take either bovine LF and LPO-containing tablets (test group, n=37) or control tablets (control group, n=35) every day for 12 weeks. Periodontal parameters and levels of subgingival plaque bacteria, human and bovine LF, and endotoxin in gingival crevicular fluid (GCF) were evaluated at baseline, 1 week, 4 weeks, and 12 weeks. Significant differences were observed in GCF levels of bovine LF between the test and control groups throughout the study (P<.05). However, clinical and bacteriological parameter values proved comparable between the two groups at 1 week to 12 weeks. Therefore, the effect of oral administration of LF and LPO-containing tablets might be weak on periodontal and bacteriological profile in this study. |
| format | Article |
| id | doaj-art-51a11137341d42e8ba0936458b75d5b5 |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-51a11137341d42e8ba0936458b75d5b52025-02-03T00:59:33ZengWileyInternational Journal of Dentistry1687-87281687-87362011-01-01201110.1155/2011/405139405139Effects of Orally Administered Lactoferrin and Lactoperoxidase-Containing Tablets on Clinical and Bacteriological Profiles in Chronic Periodontitis PatientsEiju Shimizu0Tetsuo Kobayashi1Hiroyuki Wakabayashi2Koji Yamauchi3Keiji Iwatsuki4Hiromasa Yoshie5Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JapanDivision of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JapanFood Science & Technology Institute, Morinaga Milk Industry Co., Ltd., Zama, JapanFood Science & Technology Institute, Morinaga Milk Industry Co., Ltd., Zama, JapanFood Science & Technology Institute, Morinaga Milk Industry Co., Ltd., Zama, JapanDivision of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JapanThis study was undertaken to evaluate the effect of oral administration of lactoferrin (LF) and lactoperoxidase-(LPO-)containing tablet on periodontal condition. Seventy-two individuals with chronic periodontitis were randomly assigned to take either bovine LF and LPO-containing tablets (test group, n=37) or control tablets (control group, n=35) every day for 12 weeks. Periodontal parameters and levels of subgingival plaque bacteria, human and bovine LF, and endotoxin in gingival crevicular fluid (GCF) were evaluated at baseline, 1 week, 4 weeks, and 12 weeks. Significant differences were observed in GCF levels of bovine LF between the test and control groups throughout the study (P<.05). However, clinical and bacteriological parameter values proved comparable between the two groups at 1 week to 12 weeks. Therefore, the effect of oral administration of LF and LPO-containing tablets might be weak on periodontal and bacteriological profile in this study.http://dx.doi.org/10.1155/2011/405139 |
| spellingShingle | Eiju Shimizu Tetsuo Kobayashi Hiroyuki Wakabayashi Koji Yamauchi Keiji Iwatsuki Hiromasa Yoshie Effects of Orally Administered Lactoferrin and Lactoperoxidase-Containing Tablets on Clinical and Bacteriological Profiles in Chronic Periodontitis Patients International Journal of Dentistry |
| title | Effects of Orally Administered Lactoferrin and Lactoperoxidase-Containing Tablets on Clinical and Bacteriological Profiles in Chronic Periodontitis Patients |
| title_full | Effects of Orally Administered Lactoferrin and Lactoperoxidase-Containing Tablets on Clinical and Bacteriological Profiles in Chronic Periodontitis Patients |
| title_fullStr | Effects of Orally Administered Lactoferrin and Lactoperoxidase-Containing Tablets on Clinical and Bacteriological Profiles in Chronic Periodontitis Patients |
| title_full_unstemmed | Effects of Orally Administered Lactoferrin and Lactoperoxidase-Containing Tablets on Clinical and Bacteriological Profiles in Chronic Periodontitis Patients |
| title_short | Effects of Orally Administered Lactoferrin and Lactoperoxidase-Containing Tablets on Clinical and Bacteriological Profiles in Chronic Periodontitis Patients |
| title_sort | effects of orally administered lactoferrin and lactoperoxidase containing tablets on clinical and bacteriological profiles in chronic periodontitis patients |
| url | http://dx.doi.org/10.1155/2011/405139 |
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