Reduction of inflammatory biomarkers underlies extracellular vesicle mediated functional recovery in an aged monkey model of cortical injury

Reduction of inflammatory biomarkers underlies extracellular vesicle mediated functional recovery in an aged monkey model of cortical injury

Cortical injury results in inflammation and cell death that can cause disability, especially in the aged population. Previous studies from our group have demonstrated the efficacy of bone marrow mesenchymal stromal cell derived extracellular vesicles (MSC-EVs) as a therapeutic to mitigate damage and...

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Main Authors: Ryan P. McCann, Bethany Bowley, Monica Pessina, Qiong Yang, Hongqi Xin, Sarah A. DeVries, Mingjin Wang, Yi Zhang, Michael Chopp, Zhenggang Zhang, Douglas L. Rosene, Ella Zeldich, Maria Medalla, Tara L. Moore
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
rhesus monkey
extracellular vesicle
cortical injury
microglia
inflammation
motor function
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1605144/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2025.1605144/full

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