Integrative Transcriptome‐Wide Association Study With Expression Quantitative Trait Loci Colocalization Identifies a Causal VAMP8 Variant for Nasopharyngeal Carcinoma Susceptibility

Integrative Transcriptome‐Wide Association Study With Expression Quantitative Trait Loci Colocalization Identifies a Causal VAMP8 Variant for Nasopharyngeal Carcinoma Susceptibility

Abstract Nasopharyngeal carcinoma (NPC) is an Asia‐prevalent malignancy, yet its genetic underpinnings remain incompletely understood. Here, a transcriptome‐wide association study (TWAS) is conducted on NPC, leveraging gene expression prediction models based on epithelial tissues and genome‐wide ass...

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Main Authors: Yan Liang, Xiang‐Yu Xiong, Guo‐Wang Lin, Xiaomeng Bai, Fugui Li, Josephine Mun‐Yee Ko, Yun‐He Zhou, An‐Yi Xu, Shu‐Qiang Liu, Shuai He, Pan‐Pan Wei, Qiu‐Yan Chen, Lin‐Quan Tang, Vivien Ya‐Fan Wang, Hai‐Qiang Mai, Chun‐Ling Luo, Yanni Zeng, Maria Li Lung, Mingfang Ji, Jin‐Xin Bei
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
expression quantitative trait loci (eQTL)
genome‐wide association study (GWAS)
nasopharyngeal carcinoma (NPC)
transcriptome‐wide association study (TWAS)
vesicle‐associated membrane protein 8 (VAMP8)
Online Access:https://doi.org/10.1002/advs.202412580
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https://doi.org/10.1002/advs.202412580

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