Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease
Objective. To identify, evaluate, and synthesize evidence on the predictive power of circulating endothelial progenitor cells (EPCs) in cardiovascular disease, through a systematic review of quantitative studies. Data Sources. MEDLINE was searched using keywords related to “endothelial progenitor c...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/8043792 |
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| author | Caterina Oriana Aragona Egidio Imbalzano Federica Mamone Valentina Cairo Alberto Lo Gullo Angela D’Ascola Maria Adriana Sardo Michele Scuruchi Giorgio Basile Antonino Saitta Giuseppe Mandraffino |
| author_facet | Caterina Oriana Aragona Egidio Imbalzano Federica Mamone Valentina Cairo Alberto Lo Gullo Angela D’Ascola Maria Adriana Sardo Michele Scuruchi Giorgio Basile Antonino Saitta Giuseppe Mandraffino |
| author_sort | Caterina Oriana Aragona |
| collection | DOAJ |
| description | Objective. To identify, evaluate, and synthesize evidence on the predictive power of circulating endothelial progenitor cells (EPCs) in cardiovascular disease, through a systematic review of quantitative studies.
Data Sources. MEDLINE was searched using keywords related to “endothelial progenitor cells” and “endothelium” and, for the different categories, respectively, “smoking”; “blood pressure”; “diabetes mellitus” or “insulin resistance”; “dyslipidemia”; “aging” or “elderly”; “angina pectoris” or “myocardial infarction”; “stroke” or “cerebrovascular disease”; “homocysteine”; “C-reactive protein”; “vitamin D”. Study Selection. Database hits were evaluated against explicit inclusion criteria. From 927 database hits, 43 quantitative studies were included. Data Syntheses. EPC count has been suggested for cardiovascular risk estimation in the clinical practice, since it is currently accepted that EPCs can work as proangiogenic support cells, maintaining their importance as regenerative/reparative potential, and also as prognostic markers. Conclusions. EPCs showed an important role in identifying cardiovascular risk conditions, and to suggest their evaluation as predictor of outcomes appears to be reasonable in different defined clinical settings. Due to their capability of proliferation, circulation, and the development of functional progeny, great interest has been directed to therapeutic use of progenitor cells in atherosclerotic diseases. This trial is registered with registration number: Prospero CRD42015023717. |
| format | Article |
| id | doaj-art-5150a88f3ad845d18ba71eb0823fd3ec |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-5150a88f3ad845d18ba71eb0823fd3ec2025-02-03T01:31:52ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/80437928043792Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular DiseaseCaterina Oriana Aragona0Egidio Imbalzano1Federica Mamone2Valentina Cairo3Alberto Lo Gullo4Angela D’Ascola5Maria Adriana Sardo6Michele Scuruchi7Giorgio Basile8Antonino Saitta9Giuseppe Mandraffino10Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, ItalyDepartment of Biochemical, Physiological and Nutritional Sciences, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, ItalyDepartment of Biochemical, Physiological and Nutritional Sciences, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, ItalyObjective. To identify, evaluate, and synthesize evidence on the predictive power of circulating endothelial progenitor cells (EPCs) in cardiovascular disease, through a systematic review of quantitative studies. Data Sources. MEDLINE was searched using keywords related to “endothelial progenitor cells” and “endothelium” and, for the different categories, respectively, “smoking”; “blood pressure”; “diabetes mellitus” or “insulin resistance”; “dyslipidemia”; “aging” or “elderly”; “angina pectoris” or “myocardial infarction”; “stroke” or “cerebrovascular disease”; “homocysteine”; “C-reactive protein”; “vitamin D”. Study Selection. Database hits were evaluated against explicit inclusion criteria. From 927 database hits, 43 quantitative studies were included. Data Syntheses. EPC count has been suggested for cardiovascular risk estimation in the clinical practice, since it is currently accepted that EPCs can work as proangiogenic support cells, maintaining their importance as regenerative/reparative potential, and also as prognostic markers. Conclusions. EPCs showed an important role in identifying cardiovascular risk conditions, and to suggest their evaluation as predictor of outcomes appears to be reasonable in different defined clinical settings. Due to their capability of proliferation, circulation, and the development of functional progeny, great interest has been directed to therapeutic use of progenitor cells in atherosclerotic diseases. This trial is registered with registration number: Prospero CRD42015023717.http://dx.doi.org/10.1155/2016/8043792 |
| spellingShingle | Caterina Oriana Aragona Egidio Imbalzano Federica Mamone Valentina Cairo Alberto Lo Gullo Angela D’Ascola Maria Adriana Sardo Michele Scuruchi Giorgio Basile Antonino Saitta Giuseppe Mandraffino Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease Stem Cells International |
| title | Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease |
| title_full | Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease |
| title_fullStr | Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease |
| title_full_unstemmed | Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease |
| title_short | Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease |
| title_sort | endothelial progenitor cells for diagnosis and prognosis in cardiovascular disease |
| url | http://dx.doi.org/10.1155/2016/8043792 |
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