The probability to initiate X chromosome inactivation is determined by the X to autosomal ratio and X chromosome specific allelic properties.

The probability to initiate X chromosome inactivation is determined by the X to autosomal ratio and X chromosome specific allelic properties.

<h4>Background</h4>In female mammalian cells, random X chromosome inactivation (XCI) equalizes the dosage of X-encoded gene products to that in male cells. XCI is a stochastic process, in which each X chromosome has a probability to be inactivated. To obtain more insight in the factors s...

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Main Authors: Kim Monkhorst, Bas de Hoon, Iris Jonkers, Eskeatnaf Mulugeta Achame, Wouter Monkhorst, Jos Hoogerbrugge, Eveline Rentmeester, Hans V Westerhoff, Frank Grosveld, J Anton Grootegoed, Joost Gribnau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005616&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005616&type=printable

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