The Tumor Necrosis Factor Superfamily of Cytokines in the Inflammatory Myopathies: Potential Targets for Therapy
The idiopathic inflammatory myopathies (IM) represent a heterogeneous group of autoimmune diseases, of which dermatomyositis (DM), polymyositis (PM), and sporadic inclusion body myositis (IBM) are the most common. The crucial role played by tumor necrosis factor alpha (TNFα) in the IM has long been...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/369432 |
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| author | Boel De Paepe Kim K. Creus Jan L. De Bleecker |
| author_facet | Boel De Paepe Kim K. Creus Jan L. De Bleecker |
| author_sort | Boel De Paepe |
| collection | DOAJ |
| description | The idiopathic inflammatory myopathies (IM) represent a heterogeneous group of autoimmune diseases, of which dermatomyositis (DM), polymyositis (PM), and sporadic inclusion body myositis (IBM) are the most common. The crucial role played by tumor necrosis factor alpha (TNFα) in the IM has long been recognized. However, so far, 18 other members of the TNF superfamily have been characterized, and many of these have not yet received the attention they deserve. In this paper, we summarize current findings for all TNF cytokines in IM, pinpointing what we know already and where current knowledge fails. For each TNF family member, possibilities for treating inflammatory diseases in general and the IM in particular are explored. |
| format | Article |
| id | doaj-art-50b55b4ece2e47a7b98fb5ab1c1a9df2 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-50b55b4ece2e47a7b98fb5ab1c1a9df22025-02-03T06:06:19ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/369432369432The Tumor Necrosis Factor Superfamily of Cytokines in the Inflammatory Myopathies: Potential Targets for TherapyBoel De Paepe0Kim K. Creus1Jan L. De Bleecker2Laboratory for Myopathology, Department of Neurology and Neuromuscular Reference Center, Ghent University Hospital, 9000 Ghent, BelgiumLaboratory for Myopathology, Department of Neurology and Neuromuscular Reference Center, Ghent University Hospital, 9000 Ghent, BelgiumLaboratory for Myopathology, Department of Neurology and Neuromuscular Reference Center, Ghent University Hospital, 9000 Ghent, BelgiumThe idiopathic inflammatory myopathies (IM) represent a heterogeneous group of autoimmune diseases, of which dermatomyositis (DM), polymyositis (PM), and sporadic inclusion body myositis (IBM) are the most common. The crucial role played by tumor necrosis factor alpha (TNFα) in the IM has long been recognized. However, so far, 18 other members of the TNF superfamily have been characterized, and many of these have not yet received the attention they deserve. In this paper, we summarize current findings for all TNF cytokines in IM, pinpointing what we know already and where current knowledge fails. For each TNF family member, possibilities for treating inflammatory diseases in general and the IM in particular are explored.http://dx.doi.org/10.1155/2012/369432 |
| spellingShingle | Boel De Paepe Kim K. Creus Jan L. De Bleecker The Tumor Necrosis Factor Superfamily of Cytokines in the Inflammatory Myopathies: Potential Targets for Therapy Clinical and Developmental Immunology |
| title | The Tumor Necrosis Factor Superfamily of Cytokines in the Inflammatory Myopathies: Potential Targets for Therapy |
| title_full | The Tumor Necrosis Factor Superfamily of Cytokines in the Inflammatory Myopathies: Potential Targets for Therapy |
| title_fullStr | The Tumor Necrosis Factor Superfamily of Cytokines in the Inflammatory Myopathies: Potential Targets for Therapy |
| title_full_unstemmed | The Tumor Necrosis Factor Superfamily of Cytokines in the Inflammatory Myopathies: Potential Targets for Therapy |
| title_short | The Tumor Necrosis Factor Superfamily of Cytokines in the Inflammatory Myopathies: Potential Targets for Therapy |
| title_sort | tumor necrosis factor superfamily of cytokines in the inflammatory myopathies potential targets for therapy |
| url | http://dx.doi.org/10.1155/2012/369432 |
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