Combined metabolomics and 16S rDNA sequence analyses of the gut microbiome reveal the action mechanism of Fructus Akebiae against hepatic fibrosis

Combined metabolomics and 16S rDNA sequence analyses of the gut microbiome reveal the action mechanism of Fructus Akebiae against hepatic fibrosis

ObjectivesTo explore the mechanism underlying the effect of Fructus Akebiae (FAE) against hepatic fibrosis in mice through combined network pharmacology, liver metabolomics, and 16S rDNA analyses of the gut microbiota.MethodsIn this study, we randomly divided mice into the control, model, FAE high-d...

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Bibliographic Details
Main Authors: Rong-Rong Wu, Duo-Rui Nie, Fang-Hui He, Zhi-Hang Li, Fei Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Medicine
Subjects:
Fructus Akebiae
hepatic fibrosis
network pharmacology
16s rDNA sequencing
Akkermansia
Verrucomicrobiota
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2024.1492383/full
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https://www.frontiersin.org/articles/10.3389/fmed.2024.1492383/full

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