Synthesis and Biological Evaluation of Novel Ramalin Derivatives as Multi-Target Agents for Alzheimer’s Disease

Synthesis and Biological Evaluation of Novel Ramalin Derivatives as Multi-Target Agents for Alzheimer’s Disease

Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by cognitive decline, oxidative stress, neuroinflammation, amyloid-beta (Aβ) accumulation, and tau protein hyperphosphorylation. In this study, we synthesized novel Ramalin derivatives and evaluated their therapeutic pote...

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Main Authors: Tai Kyoung Kim, Ju-Mi Hong, Yongeun Cho, Yeji Jeon, Heewon Cho, Jeongmi Lee, Jaewon Kim, Kyung Hee Kim, Il-Chan Kim, Se Jong Han, Hyuncheol Oh, Dong-Gyu Jo, Joung Han Yim
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
Alzheimer’s disease
Ramalin derivatives
antioxidant activity
anti-inflammatory activity
BACE-1 inhibition
tau aggregation
Online Access:https://www.mdpi.com/1420-3049/30/9/2030
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