Uncovering a Novel Role of ROR1 in the Epigenetic Regulation of Tumor Suppressor Gene CREB3L1 in Triple-Negative Breast Cancer Cells

Uncovering a Novel Role of ROR1 in the Epigenetic Regulation of Tumor Suppressor Gene CREB3L1 in Triple-Negative Breast Cancer Cells

A characteristic of triple-negative breast cancer (TNBC) is the epigenetic regulation of tumor suppressor genes, leading to TNBC heterogeneity and treatment resistance in patients. TNBC exhibits high methylation rates, leading to the silencing of numerous tumor suppressor genes. DNA methyltransferas...

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Bibliographic Details
Main Authors: Victoria L. Reed, Eric Lalu, Leena Yoon, Norman Fultang, Bela Peethambaran
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomolecules
Subjects:
epigenetic regulation
tumor suppressor genes
CpG methylation
TNBC
ROR1
CREB3L1
Online Access:https://www.mdpi.com/2218-273X/15/5/734
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