Adipose tissue dysfunction disrupts metabolic homeostasis: mechanisms linking fat dysregulation to disease

Adipose tissue dysfunction disrupts metabolic homeostasis: mechanisms linking fat dysregulation to disease

BackgroundMetabolic disease incidence continues rising globally. Adipose tissue dysfunction serves as a crucial pathophysiological mediator. We evaluate molecular mechanisms linking adipose dysfunction to metabolic dysregulation.MethodsWe systematically reviewed literature on adipose biology, stress...

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Main Authors: Dana Bou Matar, Mahmoud Zhra, Walid Khaled Nassar, Haifa Altemyatt, Asfiya Naureen, Nada Abotouk, Muhammad Affan Elahi, Ahmad Aljada
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Endocrinology
Subjects:
adipose tissue dysfunction
metabolic disorders
insulin resistance
inflammatory pathways
adipokine dysregulation
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1592683/full
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https://www.frontiersin.org/articles/10.3389/fendo.2025.1592683/full

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