Design, Synthesis, and Computational Evaluation of 3,4-Dihydroquinolin-2(<i>1H</i>)-One Analogues as Potential VEGFR2 Inhibitors in Glioblastoma Multiforme

Design, Synthesis, and Computational Evaluation of 3,4-Dihydroquinolin-2(<i>1H</i>)-One Analogues as Potential VEGFR2 Inhibitors in Glioblastoma Multiforme

<b>Background/Objectives</b>: Glioblastoma multiforme (GBM), an aggressive and deadly brain tumour, presents significant challenges in achieving effective treatment due to its resistance to current therapies and poor prognosis. This study aimed to synthesise and evaluate 23 novel analogu...

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Main Authors: Shafeek Buhlak, Nadeem Abad, Jihane Akachar, Sana Saffour, Yunus Kesgun, Sevval Dik, Betul Yasin, Gizem Bati-Ayaz, Essam Hanashalshahaby, Hasan Türkez, Adil Mardinoglu
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pharmaceuticals
Subjects:
glioblastoma multiforme
3,4-dihydroquinolin-2(<i>1H</i>)-one
therapeutic efficacy
molecular docking
molecular dynamics
VEGFA–VEGFR2 pathway
Online Access:https://www.mdpi.com/1424-8247/18/2/233
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