Changes in Lysine Methylation Contribute to the Cytotoxicity of Curcumin in Colon Cancer Cells

Changes in Lysine Methylation Contribute to the Cytotoxicity of Curcumin in Colon Cancer Cells

Epigenetic abnormalities play a critical role in colon carcinogenesis, making them a promising target for therapeutic interventions. In this study, we demonstrated that curcumin reduces colon cancer cell survival and that a decrease in lysine methylation was involved in such an effect. This correlat...

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Bibliographic Details
Main Authors: Roberta Santarelli, Paola Currà, Michele Di Crosta, Roberta Gonnella, Maria Saveria Gilardini Montani, Mara Cirone
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
colon cancer
curcumin
acetylation
methylation
mutp53
wtp53
Online Access:https://www.mdpi.com/1420-3049/30/2/335
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