Targeting the CLK2/SRSF9 splicing axis in prostate cancer leads to decreased ARV7 expression

Targeting the CLK2/SRSF9 splicing axis in prostate cancer leads to decreased ARV7 expression

In advanced prostate cancer (PC), in particular after acquisition of resistance to androgen receptor (AR) signaling inhibitors (ARSI), upregulation of AR splice variants compromises endocrine therapy efficiency. Androgen receptor splice variant‐7 (ARV7) is clinically the most relevant and has a dist...

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Bibliographic Details
Main Authors: Jasper Van Goubergen, Miroslav Peřina, Florian Handle, Elisa Morales, Anika Kremer, Oliver Schmidt, Glen Kristiansen, Marcus V. Cronauer, Frédéric R. Santer
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Molecular Oncology
Subjects:
3′ untranslated region
allele‐specific regulation
androgen receptor splice variant 7
dual specificity protein kinase CLK2
serine/arginine‐family of splicing factors
splicing inhibitors
Online Access:https://doi.org/10.1002/1878-0261.13728
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https://doi.org/10.1002/1878-0261.13728

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