Oscillatory Shear Stress Induces Oxidative Stress via TLR4 Activation in Endothelial Cells

Background. Oscillatory shear stress (OSS) disrupts endothelial homeostasis and promotes oxidative stress, which can lead to atherosclerosis. In atherosclerotic lesions, Toll-like receptor 4 (TLR4) is highly expressed. However, the molecular mechanism by which TLR4 modulates oxidative changes and th...

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Bibliographic Details
Main Authors: Zhimei Wang, Feng Wang, Xiangquan Kong, Xiaofei Gao, Yue Gu, Junjie Zhang
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2019/7162976
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