ABCE1 facilitates tumour progression via aerobic glycolysis and inhibits cell death in human colorectal cancer cells through the p53 signalling pathway

ABCE1 facilitates tumour progression via aerobic glycolysis and inhibits cell death in human colorectal cancer cells through the p53 signalling pathway

Abstract Colorectal cancer (CRC) poses a formidable challenge to global health, necessitating the quest for novel biomarkers to improve therapeutic strategies. This study explores ABCE1 (ATP-binding cassette subfamily E member 1) as a potential biomarker for CRC and delves into its intricate molecul...

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Main Authors: Sathan Raj Natarajan, Rajapandiyan Krishnamoorthy, Mohammad A Alshuniaber, Tawfiq S Alsulami, Mansour K. Gatasheh, Ponnulakshmi Rajagopal, Chella Perumal Palanisamy, Ramajayam Govindan, Vishnu Priya Veeraraghavan, Selvaraj Jayaraman
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Colorectal cancer
ABCE1
Biomarker
Integrated bioinformatic analysis
Irinotecan
G1 phase cell cycle arrest
Online Access:https://doi.org/10.1038/s41598-025-92436-4
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https://doi.org/10.1038/s41598-025-92436-4

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