Self-propelled ferroptosis nanoinducer for enhanced cancer therapy
Ferroptosis is a newly proposed type of programmed cell death, which has been associated with a variety of diseases including tumors. Researchers have thereby presented nanoplatforms to mediate ferroptosis for anti-cancer therapy. However, the development of ferroptosis-based nanotherapeutics is gen...
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| Format: | Article |
| Language: | English |
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IOP Publishing
2025-01-01
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| Series: | International Journal of Extreme Manufacturing |
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| Online Access: | https://doi.org/10.1088/2631-7990/ada838 |
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| author | Wenxin Xu Hao Tian Yanzhen Song Hanfeng Qin Junbin Gao Yichi Chen Weichang Huang Lin Lin Haixin Tan Yicheng Ye Xiaoting Zhang Daniela A Wilson Guang Yang Fei Peng Yingfeng Tu |
| author_facet | Wenxin Xu Hao Tian Yanzhen Song Hanfeng Qin Junbin Gao Yichi Chen Weichang Huang Lin Lin Haixin Tan Yicheng Ye Xiaoting Zhang Daniela A Wilson Guang Yang Fei Peng Yingfeng Tu |
| author_sort | Wenxin Xu |
| collection | DOAJ |
| description | Ferroptosis is a newly proposed type of programmed cell death, which has been associated with a variety of diseases including tumors. Researchers have thereby presented nanoplatforms to mediate ferroptosis for anti-cancer therapy. However, the development of ferroptosis-based nanotherapeutics is generally hindered by the limited penetration depth in tumors, poor active pharmaceutical ingredient (API) loading content and the systemic toxicity. Herein, self-propelled ferroptosis nanoinducers composed of two endogenous proteins, glucose oxidase and ferritin, are presented to show enhanced tumor inhibition via ferroptosis while maintaining high API and biocompatibility. The accumulation of our proteomotors at tumor regions is facilitated by the active tumor-targeting effect of ferritin. The enhanced diffusion of proteomotors is then actuated by efficiently decomposing glucose into gluconic acid and H _2 O _2 , leading to deeper penetration and enhanced uptake into tumors. Under the synergistic effect of glucose oxidase and ferritin, the equilibrium between reactive oxygen species and GSH is damaged, leading to lipid peroxidation. As a result, by inducing ferroptosis, our self-propelled ferroptosis nanoinducers exhibit enhanced tumor inhibitory effects. This work paves a way for the construction of a biocompatible anticancer platform with enhanced diffusion utilizing only two endogenous proteins, centered around the concept of ferroptosis. |
| format | Article |
| id | doaj-art-4f5ffb5cc56049a7bbebb6d0ffe54778 |
| institution | Kabale University |
| issn | 2631-7990 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | International Journal of Extreme Manufacturing |
| spelling | doaj-art-4f5ffb5cc56049a7bbebb6d0ffe547782025-01-24T09:09:25ZengIOP PublishingInternational Journal of Extreme Manufacturing2631-79902025-01-017303550110.1088/2631-7990/ada838Self-propelled ferroptosis nanoinducer for enhanced cancer therapyWenxin Xu0Hao Tian1Yanzhen Song2Hanfeng Qin3Junbin Gao4Yichi Chen5Weichang Huang6Lin Lin7Haixin Tan8Yicheng Ye9Xiaoting Zhang10Daniela A Wilson11Guang Yang12Fei Peng13Yingfeng Tu14https://orcid.org/0000-0003-2605-0172NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, People’s Republic of ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, People’s Republic of ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, People’s Republic of ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, People’s Republic of ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, People’s Republic of ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, People’s Republic of ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, People’s Republic of ChinaDepartment of Stomatology, Nanfang Hospital, Southern Medical University , Guangzhou 510515, People’s Republic of ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, People’s Republic of ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, People’s Republic of ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, People’s Republic of ChinaInstitute for Molecules and Materials, Radboud University , Nijmegen 6525 AJ, The NetherlandsGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai People’s Hospital (Zhuhai hospital affiliated with Jinan University) , Zhuhai 519000, People’s Republic of ChinaSchool of Materials Science and Engineering, Sun Yat-Sen University , Guangzhou 510275, People’s Republic of ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, People’s Republic of ChinaFerroptosis is a newly proposed type of programmed cell death, which has been associated with a variety of diseases including tumors. Researchers have thereby presented nanoplatforms to mediate ferroptosis for anti-cancer therapy. However, the development of ferroptosis-based nanotherapeutics is generally hindered by the limited penetration depth in tumors, poor active pharmaceutical ingredient (API) loading content and the systemic toxicity. Herein, self-propelled ferroptosis nanoinducers composed of two endogenous proteins, glucose oxidase and ferritin, are presented to show enhanced tumor inhibition via ferroptosis while maintaining high API and biocompatibility. The accumulation of our proteomotors at tumor regions is facilitated by the active tumor-targeting effect of ferritin. The enhanced diffusion of proteomotors is then actuated by efficiently decomposing glucose into gluconic acid and H _2 O _2 , leading to deeper penetration and enhanced uptake into tumors. Under the synergistic effect of glucose oxidase and ferritin, the equilibrium between reactive oxygen species and GSH is damaged, leading to lipid peroxidation. As a result, by inducing ferroptosis, our self-propelled ferroptosis nanoinducers exhibit enhanced tumor inhibitory effects. This work paves a way for the construction of a biocompatible anticancer platform with enhanced diffusion utilizing only two endogenous proteins, centered around the concept of ferroptosis.https://doi.org/10.1088/2631-7990/ada838endogenous proteinbiocompatibilityself-propelled proteomotorsenhanced diffusionferroptosis nanoinducertargeted tumor therapy |
| spellingShingle | Wenxin Xu Hao Tian Yanzhen Song Hanfeng Qin Junbin Gao Yichi Chen Weichang Huang Lin Lin Haixin Tan Yicheng Ye Xiaoting Zhang Daniela A Wilson Guang Yang Fei Peng Yingfeng Tu Self-propelled ferroptosis nanoinducer for enhanced cancer therapy International Journal of Extreme Manufacturing endogenous protein biocompatibility self-propelled proteomotors enhanced diffusion ferroptosis nanoinducer targeted tumor therapy |
| title | Self-propelled ferroptosis nanoinducer for enhanced cancer therapy |
| title_full | Self-propelled ferroptosis nanoinducer for enhanced cancer therapy |
| title_fullStr | Self-propelled ferroptosis nanoinducer for enhanced cancer therapy |
| title_full_unstemmed | Self-propelled ferroptosis nanoinducer for enhanced cancer therapy |
| title_short | Self-propelled ferroptosis nanoinducer for enhanced cancer therapy |
| title_sort | self propelled ferroptosis nanoinducer for enhanced cancer therapy |
| topic | endogenous protein biocompatibility self-propelled proteomotors enhanced diffusion ferroptosis nanoinducer targeted tumor therapy |
| url | https://doi.org/10.1088/2631-7990/ada838 |
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