Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats

The effects of tamoxifen (TAM) on anxiety and depression-like behavior in ovariectomized (OVX) and naïve female rats were investigated. The animals were divided into Sham-TAM, OVX-TAM, Sham and OVX groups. Tamoxifen (1 mg/kg) was administered for 4 weeks. In the forced swimming test, the immobility...

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Bibliographic Details
Main Authors: Hamid Azizi-Malekabadi, Masoume Pourganji, Hoda Zabihi, Mohsen Saeedjalali, Mahmoud Hosseini
Format: Article
Language:English
Published: Thieme Revinter Publicações 2015-02-01
Series:Arquivos de Neuro-Psiquiatria
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Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000200132&lng=en&tlng=en
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