Self-maintenance of zonal hepatocytes during adult homeostasis and their complex plasticity upon distinct liver injuries

Self-maintenance of zonal hepatocytes during adult homeostasis and their complex plasticity upon distinct liver injuries

Summary: Hepatocytes are organized into distinct zonal subsets across the liver lobule, yet their contributions to liver homeostasis and regeneration remain controversial. Here, we developed multiple genetic lineage-tracing mouse models to systematically address this. We found that the liver lobule...

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Main Authors: Chow Hiang Ang, Philip Arandjelovic, Jinming Cheng, Jicheng Yang, Fusheng Guo, Yuanquan Yu, Sarmilla Nelameham, Lachlan Whitehead, Jiangtao Li, David L. Silver, Nick Barker, Jane E. Visvader, Pierce K.H. Chow, Gordon K. Smyth, Yunshun Chen, David M. Virshup, Nai Yang Fu
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cell Reports
Subjects:
CP: Stem cell research
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472401444X
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