Inhibition of skin fibrosis via regulation of Th17/Treg imbalance in systemic sclerosis

Inhibition of skin fibrosis via regulation of Th17/Treg imbalance in systemic sclerosis

Abstract Systemic sclerosis (SSc) is an idiopathic systemic connective tissue disorder characterized by fibrosis of the skin and internal organs, with growing interest in the imbalance between Th17 cells and regulatory T cells (Tregs) in the disease’s pathogenesis. Heligmosomoides polygyrus (Hp), a...

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Main Authors: Akiko Sekiguchi, Chikako Shimokawa, Tamotsu Kato, Akihiko Uchiyama, Yoko Yokoyama, Sachiko Ogino, Ryoko Torii, Hajime Hisaeda, Hiroshi Ohno, Sei-ichiro Motegi
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Systemic sclerosis
Th17/Treg balance
Fibrosis
Bleomycin
Heligmosomoides polygilus
Microbiota
Online Access:https://doi.org/10.1038/s41598-025-85895-2
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https://doi.org/10.1038/s41598-025-85895-2

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