The BAMBOO method for correcting batch effects in high throughput proximity extension assays for proteomic studies

The BAMBOO method for correcting batch effects in high throughput proximity extension assays for proteomic studies

Abstract The proximity extension assay (PEA) enables large-scale proteomic investigations across numerous proteins and samples. However, discrepancies between measurements, known as batch-effects, potentially skew downstream statistical analyses and increase the risks of false discoveries. While imp...

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Bibliographic Details
Main Authors: H. M. Smits, E. M. Delemarre, A. Pandit, A. H. Schoneveld, B. Oldenburg, F. van Wijk, S. Nierkens, J. Drylewicz
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Proteomics
Large proteomic study
Batch effects
Batch effects correction
Bridging controls
Online Access:https://doi.org/10.1038/s41598-024-84320-4
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https://doi.org/10.1038/s41598-024-84320-4

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