Diagnostic challenge in chondromyxoid fibroma clinically mimicking neuroma
Chondromyxoid fibromas (CMF) are uncommon benign bone tumours, known for their moderate risk of local recurrence, that may manifest through various symptoms such as pain, swelling, tenderness, or be asymptomatic. Diagnosing CMF is challenging and requires a comprehensive, multidisciplinary diagnosti...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2024-10-01
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| Series: | Contemporary Oncology |
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| Online Access: | https://www.termedia.pl/Diagnostic-challenge-in-chondromyxoid-fibroma-clinically-mimicking-neuroma,3,54977,1,1.html |
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| author | Aleksandra Izabela Masłowska Julia Sołek Paulina Jagodzińska-Mucha Marcin Braun Hanna Romańska |
| author_facet | Aleksandra Izabela Masłowska Julia Sołek Paulina Jagodzińska-Mucha Marcin Braun Hanna Romańska |
| author_sort | Aleksandra Izabela Masłowska |
| collection | DOAJ |
| description | Chondromyxoid fibromas (CMF) are uncommon benign bone tumours, known for their moderate risk of local recurrence, that may manifest through various symptoms such as pain, swelling, tenderness, or be asymptomatic. Diagnosing CMF is challenging and requires a comprehensive, multidisciplinary diagnostic approach because the tumour frequently resembles numerous other bone lesions. This report describes a case of a 66-year-old female patient with a tumour in her right fibula. The initial diagnosis of a neuroma of the right tibial nerve was based on a magnetic resonance imaging scan. The lesion was surgically removed. Preliminarily subsequent histopathological evaluation identified the mass as a parosteal osteosarcoma. However, due to the uncharacteristic presentation of the tumour, further investigation was carried out. Using immunohistochemical and genetic analyses focused on the expression of MDM-2 and RB-1, along with an examination for alterations in the GNAS gene, the mass has been finally and conclusively identified as a chondromyxoid fibroma. This case demonstrates the ambiguity of the CMF presentation, the accurate diagnosis of which may frequently rely on additional diagnostic measures, including histopathology and targeted genetic tests. Furthermore, this report illustrates an atypical diagnostic journey, from an initial neuroma through a low-grade osteosarcoma, to a final benign chondromyxoid fibroma. |
| format | Article |
| id | doaj-art-4e767cdb239a414db5fdc5a2a9e6f00f |
| institution | Kabale University |
| issn | 1428-2526 1897-4309 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Contemporary Oncology |
| spelling | doaj-art-4e767cdb239a414db5fdc5a2a9e6f00f2025-01-27T11:19:22ZengTermedia Publishing HouseContemporary Oncology1428-25261897-43092024-10-0128326726910.5114/wo.2024.14408154977Diagnostic challenge in chondromyxoid fibroma clinically mimicking neuromaAleksandra Izabela MasłowskaJulia SołekPaulina Jagodzińska-MuchaMarcin BraunHanna RomańskaChondromyxoid fibromas (CMF) are uncommon benign bone tumours, known for their moderate risk of local recurrence, that may manifest through various symptoms such as pain, swelling, tenderness, or be asymptomatic. Diagnosing CMF is challenging and requires a comprehensive, multidisciplinary diagnostic approach because the tumour frequently resembles numerous other bone lesions. This report describes a case of a 66-year-old female patient with a tumour in her right fibula. The initial diagnosis of a neuroma of the right tibial nerve was based on a magnetic resonance imaging scan. The lesion was surgically removed. Preliminarily subsequent histopathological evaluation identified the mass as a parosteal osteosarcoma. However, due to the uncharacteristic presentation of the tumour, further investigation was carried out. Using immunohistochemical and genetic analyses focused on the expression of MDM-2 and RB-1, along with an examination for alterations in the GNAS gene, the mass has been finally and conclusively identified as a chondromyxoid fibroma. This case demonstrates the ambiguity of the CMF presentation, the accurate diagnosis of which may frequently rely on additional diagnostic measures, including histopathology and targeted genetic tests. Furthermore, this report illustrates an atypical diagnostic journey, from an initial neuroma through a low-grade osteosarcoma, to a final benign chondromyxoid fibroma.https://www.termedia.pl/Diagnostic-challenge-in-chondromyxoid-fibroma-clinically-mimicking-neuroma,3,54977,1,1.htmldiagnosis bone tumour chondromyxoid fibroma benign cartilaginous tumour |
| spellingShingle | Aleksandra Izabela Masłowska Julia Sołek Paulina Jagodzińska-Mucha Marcin Braun Hanna Romańska Diagnostic challenge in chondromyxoid fibroma clinically mimicking neuroma Contemporary Oncology diagnosis bone tumour chondromyxoid fibroma benign cartilaginous tumour |
| title | Diagnostic challenge in chondromyxoid fibroma clinically mimicking neuroma |
| title_full | Diagnostic challenge in chondromyxoid fibroma clinically mimicking neuroma |
| title_fullStr | Diagnostic challenge in chondromyxoid fibroma clinically mimicking neuroma |
| title_full_unstemmed | Diagnostic challenge in chondromyxoid fibroma clinically mimicking neuroma |
| title_short | Diagnostic challenge in chondromyxoid fibroma clinically mimicking neuroma |
| title_sort | diagnostic challenge in chondromyxoid fibroma clinically mimicking neuroma |
| topic | diagnosis bone tumour chondromyxoid fibroma benign cartilaginous tumour |
| url | https://www.termedia.pl/Diagnostic-challenge-in-chondromyxoid-fibroma-clinically-mimicking-neuroma,3,54977,1,1.html |
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