In Silico and In Vivo Evaluation of a New Derivative from Memantine and Sinapic Acid (<i>N</i>-Sinapoyl-memantine) as a Candidate for the Management of Alzheimer’s Disease

In Silico and In Vivo Evaluation of a New Derivative from Memantine and Sinapic Acid (<i>N</i>-Sinapoyl-memantine) as a Candidate for the Management of Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common neurodegenerative disease which has a rather complex pathophysiology. During its course, several neurotransmitter neuronal systems get affected such as acetylcholinergic, glutamatergic, <i>gamma</i>-aminobutyric acid (GABA)ergic systems, etc. S...

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Bibliographic Details
Main Authors: Andrey Popatanasov, Lyubka Tancheva, Reni Kalfin, Maya Chochkova
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Crystals
Subjects:
sinapic acid
memantine
Alzheimer’s disease
molecular docking
molecular drug design
acetylcholinesterase inhibitor
Online Access:https://www.mdpi.com/2073-4352/15/6/491
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