Analysis of macular retinal thickness in polyarteritis nodosa using spectral domain optical coherence tomography
Abstract Purpose To identify the macular retinal layer thickness changes in polyarteritis nodosa (PAN) patients without pathological findings appearing in color fundus photography (CFP), and to investigate the correlations with disease durations. Methods A total of 24 PAN patients who had been for 3...
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SpringerOpen
2025-01-01
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| Series: | Journal of Ophthalmic Inflammation and Infection |
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| Online Access: | https://doi.org/10.1186/s12348-025-00453-1 |
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| author | Che-Ning Yang Chia-Ping Chen Yi-Ting Hsieh |
| author_facet | Che-Ning Yang Chia-Ping Chen Yi-Ting Hsieh |
| author_sort | Che-Ning Yang |
| collection | DOAJ |
| description | Abstract Purpose To identify the macular retinal layer thickness changes in polyarteritis nodosa (PAN) patients without pathological findings appearing in color fundus photography (CFP), and to investigate the correlations with disease durations. Methods A total of 24 PAN patients who had been for 3 years or more and underwent SD-OCT were recruited from the UK Biobank, with exclusions for diabetes, eye disease, or abnormal CFP findings. Only the right eyes were included, with each PAN patient paired one-to-one with a control matched for age, sex, and ethnicity. Paired t-tests or Wilcoxon Signed-Rank tests were used to assess the differences in thickness of different retinal layers between groups, followed by linear regression analysis to evaluate the correlations with disease durations. Results PAN patients had significantly thinner retinal nerve fiber layer (RNFL) by 12.27% (mean ± standard deviation = 27.39 ± 8.94 μm for PAN patients and 31.22 ± 5.57 μm for controls, p = 0.048) and thinner outer plexiform and outer nuclear layers (OPL-ONL complex) by 10.67% (44.93 ± 6.59 μm for PAN patients and 50.31 ± 7.60 μm for controls, p = 0.032). Visual acuity and the whole macular thickness showed no statistical difference. The RNFL was thinned by 1.22 μm per year of disease progression (95% confidence interval: 0.12, 2.32, p = 0.042). Conclusions PAN patients without visual impairments or abnormal CFP findings may exhibit significant thinning in RNFL and OPL-ONL complex. SD-OCT may serve as a useful tool for early screening of ophthalmic changes in PAN. |
| format | Article |
| id | doaj-art-4e72daeb17e643b29a5bcdfb446e8bd7 |
| institution | Kabale University |
| issn | 1869-5760 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
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| series | Journal of Ophthalmic Inflammation and Infection |
| spelling | doaj-art-4e72daeb17e643b29a5bcdfb446e8bd72025-01-19T12:34:59ZengSpringerOpenJournal of Ophthalmic Inflammation and Infection1869-57602025-01-011511810.1186/s12348-025-00453-1Analysis of macular retinal thickness in polyarteritis nodosa using spectral domain optical coherence tomographyChe-Ning Yang0Chia-Ping Chen1Yi-Ting Hsieh2School of Medicine, National Taiwan UniversityDepartment of Medical Education, National Taiwan University HospitalSchool of Medicine, National Taiwan UniversityAbstract Purpose To identify the macular retinal layer thickness changes in polyarteritis nodosa (PAN) patients without pathological findings appearing in color fundus photography (CFP), and to investigate the correlations with disease durations. Methods A total of 24 PAN patients who had been for 3 years or more and underwent SD-OCT were recruited from the UK Biobank, with exclusions for diabetes, eye disease, or abnormal CFP findings. Only the right eyes were included, with each PAN patient paired one-to-one with a control matched for age, sex, and ethnicity. Paired t-tests or Wilcoxon Signed-Rank tests were used to assess the differences in thickness of different retinal layers between groups, followed by linear regression analysis to evaluate the correlations with disease durations. Results PAN patients had significantly thinner retinal nerve fiber layer (RNFL) by 12.27% (mean ± standard deviation = 27.39 ± 8.94 μm for PAN patients and 31.22 ± 5.57 μm for controls, p = 0.048) and thinner outer plexiform and outer nuclear layers (OPL-ONL complex) by 10.67% (44.93 ± 6.59 μm for PAN patients and 50.31 ± 7.60 μm for controls, p = 0.032). Visual acuity and the whole macular thickness showed no statistical difference. The RNFL was thinned by 1.22 μm per year of disease progression (95% confidence interval: 0.12, 2.32, p = 0.042). Conclusions PAN patients without visual impairments or abnormal CFP findings may exhibit significant thinning in RNFL and OPL-ONL complex. SD-OCT may serve as a useful tool for early screening of ophthalmic changes in PAN.https://doi.org/10.1186/s12348-025-00453-1Polyarteritis nodosaOptical coherence tomographyRetinal layer thicknessRetinal nerve fiber layer |
| spellingShingle | Che-Ning Yang Chia-Ping Chen Yi-Ting Hsieh Analysis of macular retinal thickness in polyarteritis nodosa using spectral domain optical coherence tomography Journal of Ophthalmic Inflammation and Infection Polyarteritis nodosa Optical coherence tomography Retinal layer thickness Retinal nerve fiber layer |
| title | Analysis of macular retinal thickness in polyarteritis nodosa using spectral domain optical coherence tomography |
| title_full | Analysis of macular retinal thickness in polyarteritis nodosa using spectral domain optical coherence tomography |
| title_fullStr | Analysis of macular retinal thickness in polyarteritis nodosa using spectral domain optical coherence tomography |
| title_full_unstemmed | Analysis of macular retinal thickness in polyarteritis nodosa using spectral domain optical coherence tomography |
| title_short | Analysis of macular retinal thickness in polyarteritis nodosa using spectral domain optical coherence tomography |
| title_sort | analysis of macular retinal thickness in polyarteritis nodosa using spectral domain optical coherence tomography |
| topic | Polyarteritis nodosa Optical coherence tomography Retinal layer thickness Retinal nerve fiber layer |
| url | https://doi.org/10.1186/s12348-025-00453-1 |
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