Human induced pluripotent stem cell-derived dopaminergic neurons release alpha-synuclein through neuronal activity

Human induced pluripotent stem cell-derived dopaminergic neurons release alpha-synuclein through neuronal activity

Lewy body diseases, including Parkinson's disease (PD), are characterized by the spread of alpha-synuclein (αSyn) between neurons across synapses, a process crucial for understanding their pathophysiology and developing effective treatments. In this study, we aimed to investigate the role of ne...

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Bibliographic Details
Main Authors: Maierdanjiang Nuermaimaiti, Kei-ichi Ishikawa, Genko Oyama, Risa Nonaka, Takahiro Shiga, Takayuki Jo, Taiji Tsunemi, Ryota Nakamura, Rejko Krüger, Wado Akamatsu, Nobutaka Hattori
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neuroscience Research
Subjects:
Alpha-synuclein
Neuronal activity
Propagation
Parkinson’s disease
Lewy body disease
Human iPS cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0168010224001408
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