Cefiderocol activity against planktonic and biofilm forms of β-lactamase-producing pseudomonas aeruginosa from people with cystic fibrosis

Cefiderocol activity against planktonic and biofilm forms of β-lactamase-producing pseudomonas aeruginosa from people with cystic fibrosis

Objectives: Chronic Pseudomonas aeruginosa infections are a leading cause of acute pulmonary exacerbations in people with cystic fibrosis (pwCF). Intrinsic antibiotic resistance and biofilm formation complicate treatment. This study investigates the genomic diversity and cefiderocol efficacy against...

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Main Authors: Giorgia Fabrizio, Mauro Truglio, Ilaria Cavallo, Francesca Sivori, Massimo Francalancia, Rodolfo J. Riveros Cabral, Manola Comar, Maria Trancassini, Daniele Emanuele Compagnino, Fabiana Diaco, Guido Antonelli, Fiorentina Ascenzioni, Giuseppe Cimino, Fulvia Pimpinelli, Enea Gino Di Domenico
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
Cystic fibrosis
Pseudomonas aeruginosa
Cefiderocol
Biofilm
Avibactam
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716525000827
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