Causal Associations Between the Gut Microbiota and Hypertension‐Related Traits Through Mendelian Randomization: A Cross‐Sectional Cohort Study
ABSTRACT Previous studies have suggested a link between the gut microbiome and hypertension‐related traits like blood pressure. However, these reports are often limited by weak causal evidence. This study investigates the potential causal association between gut microbiota and hypertension‐related t...
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| Format: | Article |
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Wiley
2025-01-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.14925 |
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| author | Yunfan Tian Mingxia Gu Dazhong Chen Quanbin Dong Yifeng Wang Wei Sun Xiangqing Kong |
| author_facet | Yunfan Tian Mingxia Gu Dazhong Chen Quanbin Dong Yifeng Wang Wei Sun Xiangqing Kong |
| author_sort | Yunfan Tian |
| collection | DOAJ |
| description | ABSTRACT Previous studies have suggested a link between the gut microbiome and hypertension‐related traits like blood pressure. However, these reports are often limited by weak causal evidence. This study investigates the potential causal association between gut microbiota and hypertension‐related traits using Mendelian randomization with summary data from genome‐wide association studies. The inverse‐variance weighted method revealed that the Clostridium innocuum group (Odds ratio [OR]: 1.0047, 95% confidence interval [CI]: 1.0004–1.0090, p = 0.0336), Eubacterium fissicatena group (OR: 1.0047, 95% CI: 1.0005–1.0088, p = 0.0266), Lachnospiraceae FCS020 group (OR: 1.0063, 95% CI: 1.0004–1.0122, p = 0.0361), and Olsenella (OR: 1.0044, 95% CI: 1.0001–1.0088, p = 0.0430) were associated with an increased risk of hypertension. Conversely, Flavonifractor (OR: 0.9901, 95% CI: 0.9821–0.9982, p = 0.0166), Parabacteroides (OR: 0.9874, 95% CI: 0.9776–0.9972, p = 0.0121), and Senegalimassilia (OR: 0.9907, 95% CI: 0.9842–0.9974, p = 0.0063) were associated with a decreased risk of hypertension. External validation with the Guangdong Gut Microbiome Project confirmed a negative correlation between Parabacteroides and hypertension, potentially through metabolic pathways. These findings provide further evidence supporting the hypothesis that microbes and their metabolites play a role in blood pressure regulation. |
| format | Article |
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| institution | Kabale University |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-4e47c66bb5d8421283b169d885a2bedf2025-01-31T05:38:37ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762025-01-01271n/an/a10.1111/jch.14925Causal Associations Between the Gut Microbiota and Hypertension‐Related Traits Through Mendelian Randomization: A Cross‐Sectional Cohort StudyYunfan Tian0Mingxia Gu1Dazhong Chen2Quanbin Dong3Yifeng Wang4Wei Sun5Xiangqing Kong6Department of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of pharmacy 920th Hospital of Joint Logistics Support Force Kunming ChinaDepartment of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaABSTRACT Previous studies have suggested a link between the gut microbiome and hypertension‐related traits like blood pressure. However, these reports are often limited by weak causal evidence. This study investigates the potential causal association between gut microbiota and hypertension‐related traits using Mendelian randomization with summary data from genome‐wide association studies. The inverse‐variance weighted method revealed that the Clostridium innocuum group (Odds ratio [OR]: 1.0047, 95% confidence interval [CI]: 1.0004–1.0090, p = 0.0336), Eubacterium fissicatena group (OR: 1.0047, 95% CI: 1.0005–1.0088, p = 0.0266), Lachnospiraceae FCS020 group (OR: 1.0063, 95% CI: 1.0004–1.0122, p = 0.0361), and Olsenella (OR: 1.0044, 95% CI: 1.0001–1.0088, p = 0.0430) were associated with an increased risk of hypertension. Conversely, Flavonifractor (OR: 0.9901, 95% CI: 0.9821–0.9982, p = 0.0166), Parabacteroides (OR: 0.9874, 95% CI: 0.9776–0.9972, p = 0.0121), and Senegalimassilia (OR: 0.9907, 95% CI: 0.9842–0.9974, p = 0.0063) were associated with a decreased risk of hypertension. External validation with the Guangdong Gut Microbiome Project confirmed a negative correlation between Parabacteroides and hypertension, potentially through metabolic pathways. These findings provide further evidence supporting the hypothesis that microbes and their metabolites play a role in blood pressure regulation.https://doi.org/10.1111/jch.14925gut microbiotahypertensionMendelian randomizationparabacteroidespathway |
| spellingShingle | Yunfan Tian Mingxia Gu Dazhong Chen Quanbin Dong Yifeng Wang Wei Sun Xiangqing Kong Causal Associations Between the Gut Microbiota and Hypertension‐Related Traits Through Mendelian Randomization: A Cross‐Sectional Cohort Study The Journal of Clinical Hypertension gut microbiota hypertension Mendelian randomization parabacteroides pathway |
| title | Causal Associations Between the Gut Microbiota and Hypertension‐Related Traits Through Mendelian Randomization: A Cross‐Sectional Cohort Study |
| title_full | Causal Associations Between the Gut Microbiota and Hypertension‐Related Traits Through Mendelian Randomization: A Cross‐Sectional Cohort Study |
| title_fullStr | Causal Associations Between the Gut Microbiota and Hypertension‐Related Traits Through Mendelian Randomization: A Cross‐Sectional Cohort Study |
| title_full_unstemmed | Causal Associations Between the Gut Microbiota and Hypertension‐Related Traits Through Mendelian Randomization: A Cross‐Sectional Cohort Study |
| title_short | Causal Associations Between the Gut Microbiota and Hypertension‐Related Traits Through Mendelian Randomization: A Cross‐Sectional Cohort Study |
| title_sort | causal associations between the gut microbiota and hypertension related traits through mendelian randomization a cross sectional cohort study |
| topic | gut microbiota hypertension Mendelian randomization parabacteroides pathway |
| url | https://doi.org/10.1111/jch.14925 |
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