Theoretical modeling of hepatitis C acute infection in liver-humanized mice support pre-clinical assessment of candidate viruses for controlled-human-infection studies

Theoretical modeling of hepatitis C acute infection in liver-humanized mice support pre-clinical assessment of candidate viruses for controlled-human-infection studies

Abstract Designing and carrying out a controlled human infection (CHI) model for hepatitis C virus (HCV) is critical for vaccine development. However, key considerations for a CHI model protocol include understanding of the earliest viral-host kinetic events during the acute phase and susceptibility...

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Main Authors: Zhenzhen Shi, Adquate Mhlanga, Yuji Ishida, Ari Josephson, Nicholson T. Collier, Hiromi Abe-Chayama, Chise Tateno-Mukaidani, Scott J. Cotler, Jonathan Ozik, Marian Major, Jordan J. Feld, Kazuaki Chayama, Harel Dahari
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Hepatitis C virus
Agent-based modeling
Ordinary differential equations
Liver-humanized mouse model
Controlled human infection model
Online Access:https://doi.org/10.1038/s41598-024-83104-0
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https://doi.org/10.1038/s41598-024-83104-0

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