Prognostic Value of Cerebrospinal Fluid and Serum Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: A Correlation Study
ABSTRACT Background The diagnostic and prognostic values of serum neurofilament light chain (sNfL), in comparison to cerebrospinal fluid (CSF) neurofilament light chain (cNfL), and other clinical parameters in amyotrophic lateral sclerosis (ALS) at the time of diagnosis remain elusive. Methods We ex...
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Wiley
2025-01-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70256 |
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| author | Siqi Dong Xiaoni Liu Yanni Zhou Jiatong Li Zihan Qi Zihan Wang Wenbo Yang Xiangjun Chen |
| author_facet | Siqi Dong Xiaoni Liu Yanni Zhou Jiatong Li Zihan Qi Zihan Wang Wenbo Yang Xiangjun Chen |
| author_sort | Siqi Dong |
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| description | ABSTRACT Background The diagnostic and prognostic values of serum neurofilament light chain (sNfL), in comparison to cerebrospinal fluid (CSF) neurofilament light chain (cNfL), and other clinical parameters in amyotrophic lateral sclerosis (ALS) at the time of diagnosis remain elusive. Methods We examine paired serum and CSF samples from 80 ALS patients and 21 control subjects, all obtained at the time of diagnosis. Additional serum samples were collected from 51 other ALS patients. NfL concentrations were quantified using the single molecule array (Simoa) technique. Results Our findings demonstrate a robust correlation between NfL levels in matched CSF and serum samples. Notably, both sNfL (p < 0.0001) and cNfL (p < 0.0001) exhibited significantly elevated levels in ALS patients compared to controls. Furthermore, baseline sNfL concentrations, as well as cNfL levels, emerged as predictive indicators of subsequent disease progression rate (sNfL: p < 0.0001, cNfL: p = 0.0005) and overall survival (sNfL: p = 0.0073, cNfL: p = 0.0044). Employing a Cox regression model, we identified baseline sNfL level (HR = 1.01, p = 0.013), and diagnostic delay (HR = 0.94, p = 0.003) as independent prognostic factors for mortality. Furthermore, we constructed a nomogram model that incorporates both sNfL and pertinent clinical variables, which substantially enhances the accuracy of predicting disease outcomes (Concordance Index, 0.808). Conclusion Our study underscores the robust correlation between sNfL and cNfL in ALS patients and establishes baseline sNfL as a potent and independent prognostic marker for mortality. |
| format | Article |
| id | doaj-art-4e36f1994fe542cf9de23d069bf482b9 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | Brain and Behavior |
| spelling | doaj-art-4e36f1994fe542cf9de23d069bf482b92025-01-29T13:36:40ZengWileyBrain and Behavior2162-32792025-01-01151n/an/a10.1002/brb3.70256Prognostic Value of Cerebrospinal Fluid and Serum Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: A Correlation StudySiqi Dong0Xiaoni Liu1Yanni Zhou2Jiatong Li3Zihan Qi4Zihan Wang5Wenbo Yang6Xiangjun Chen7Department of Neurology, Huashan Hospital Fudan University Shanghai People's Republic of ChinaDepartment of Neurology, Huashan Hospital Fudan University Shanghai People's Republic of ChinaDepartment of Anthropology and Human Genetics, School of Life Sciences Fudan University Shanghai People's Republic of ChinaDepartment of Neurology, Huashan Hospital Fudan University Shanghai People's Republic of ChinaDepartment of Neurology, Huashan Hospital Fudan University Shanghai People's Republic of ChinaDepartment of Neurology, Huashan Hospital Fudan University Shanghai People's Republic of ChinaDepartment of Neurology, Huashan Hospital Fudan University Shanghai People's Republic of ChinaDepartment of Neurology, Huashan Hospital Fudan University Shanghai People's Republic of ChinaABSTRACT Background The diagnostic and prognostic values of serum neurofilament light chain (sNfL), in comparison to cerebrospinal fluid (CSF) neurofilament light chain (cNfL), and other clinical parameters in amyotrophic lateral sclerosis (ALS) at the time of diagnosis remain elusive. Methods We examine paired serum and CSF samples from 80 ALS patients and 21 control subjects, all obtained at the time of diagnosis. Additional serum samples were collected from 51 other ALS patients. NfL concentrations were quantified using the single molecule array (Simoa) technique. Results Our findings demonstrate a robust correlation between NfL levels in matched CSF and serum samples. Notably, both sNfL (p < 0.0001) and cNfL (p < 0.0001) exhibited significantly elevated levels in ALS patients compared to controls. Furthermore, baseline sNfL concentrations, as well as cNfL levels, emerged as predictive indicators of subsequent disease progression rate (sNfL: p < 0.0001, cNfL: p = 0.0005) and overall survival (sNfL: p = 0.0073, cNfL: p = 0.0044). Employing a Cox regression model, we identified baseline sNfL level (HR = 1.01, p = 0.013), and diagnostic delay (HR = 0.94, p = 0.003) as independent prognostic factors for mortality. Furthermore, we constructed a nomogram model that incorporates both sNfL and pertinent clinical variables, which substantially enhances the accuracy of predicting disease outcomes (Concordance Index, 0.808). Conclusion Our study underscores the robust correlation between sNfL and cNfL in ALS patients and establishes baseline sNfL as a potent and independent prognostic marker for mortality.https://doi.org/10.1002/brb3.70256amyotrophic lateral sclerosisbiomarkerdiagnosisneurofilament light chainprognosis |
| spellingShingle | Siqi Dong Xiaoni Liu Yanni Zhou Jiatong Li Zihan Qi Zihan Wang Wenbo Yang Xiangjun Chen Prognostic Value of Cerebrospinal Fluid and Serum Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: A Correlation Study Brain and Behavior amyotrophic lateral sclerosis biomarker diagnosis neurofilament light chain prognosis |
| title | Prognostic Value of Cerebrospinal Fluid and Serum Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: A Correlation Study |
| title_full | Prognostic Value of Cerebrospinal Fluid and Serum Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: A Correlation Study |
| title_fullStr | Prognostic Value of Cerebrospinal Fluid and Serum Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: A Correlation Study |
| title_full_unstemmed | Prognostic Value of Cerebrospinal Fluid and Serum Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: A Correlation Study |
| title_short | Prognostic Value of Cerebrospinal Fluid and Serum Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: A Correlation Study |
| title_sort | prognostic value of cerebrospinal fluid and serum neurofilament light chain in amyotrophic lateral sclerosis a correlation study |
| topic | amyotrophic lateral sclerosis biomarker diagnosis neurofilament light chain prognosis |
| url | https://doi.org/10.1002/brb3.70256 |
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