Neoantigen-based mRNA vaccine exhibits superior anti-tumor activity compared to synthetic long peptides in an in vivo lung carcinoma model

Neoantigen-based mRNA vaccine exhibits superior anti-tumor activity compared to synthetic long peptides in an in vivo lung carcinoma model

Abstract Neoantigen vaccines hold great promise in cancer immunotherapy, but the comparative efficacy of different vaccine platforms, particularly in the context of tumor burden (TB), remains insufficiently studied. In this research, we evaluated the safety and therapeutic efficacy of synthetic long...

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Bibliographic Details
Main Authors: Cao Minh Nguyen, Trung T. Vu, Minh Nguyen Nguyen, Thao-Suong Tran-Nguyen, Chi Thien Huynh, Quang Thanh Ha, Hoai-Nghia Nguyen, Le Son Tran
Format: Article
Language:English
Published: Springer 2025-03-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Lewis lung carcinoma
Neoantigen
Synthetic long peptide vaccine
mRNA-based vaccine
mRNA-LNPs
Cancer immunotherapy
Online Access:https://doi.org/10.1007/s00262-025-03992-7
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https://doi.org/10.1007/s00262-025-03992-7

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