Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease

Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease

Abstract Background Pathological deposition of hyperphosphorylated tau in the brain closely correlates with the course of Alzheimer’s disease (AD). Tau pathology occurs in axons of affected neurons and tau removal from axons might thus be an early intervention strategy. Methods We investigated the r...

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Main Authors: Abdolhossein Zare, Saeede Salehi, Jakob M. Bader, Anna-Lena Wiessler, Manuela Prokesch, Vincent Albrecht, Carmen Villmann, Matthias Mann, Michael Briese, Michael Sendtner
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Translational Neurodegeneration
Subjects:
Alzheimer’s disease
Tau
Mapt
Amyloid
hnRNP R
Antisense oligonucleotide
Online Access:https://doi.org/10.1186/s40035-025-00499-0
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https://doi.org/10.1186/s40035-025-00499-0

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