Systems Biological Approaches Reveal Non-additive Responses and Multiple Crosstalk Mechanisms between TLR and GPCR Signaling

Systems Biological Approaches Reveal Non-additive Responses and Multiple Crosstalk Mechanisms between TLR and GPCR Signaling

A variety of ligands differ in their capacity to bind the receptor, elicit gene expression, and modulate physiological responses. Such receptors include Toll-like receptors (TLRs), which recognize various patterns of pathogens and lead to primary innate immune activation against invaders, and G-prot...

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Bibliographic Details
Main Authors: Jayalakshmi Krishnan, Sangdun Choi
Format: Article
Language:English
Published: BioMed Central 2012-09-01
Series:Genomics & Informatics
Subjects:
gene expression
G-protein coupled receptors
immune responses
innate immunity
macrophages
Toll-like receptors
Online Access:http://genominfo.org/upload/pdf/gni-10-153.pdf
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http://genominfo.org/upload/pdf/gni-10-153.pdf

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