EphrinB2 alleviates tubulointerstitial fibrosis in diabetic kidney disease

EphrinB2 alleviates tubulointerstitial fibrosis in diabetic kidney disease

Abstract Background Diabetic kidney disease (DKD) is characterized by progressive fibrosis, oxidative stress, and mitochondrial dysfunction, contributing to renal dysfunction. EphrinB2, a cell surface protein, has been implicated in tissue repair and fibrosis, but its role in DKD remains poorly unde...

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Bibliographic Details
Main Authors: Lihua Ni, Qiuyuan Zhou, Xueyun Gao, Feng Chen, Ayinigaer Yusufu, Jin-Hu Chen, Cheng Yuan, Xiaoyan Wu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Diabetic kidney disease (DKD)
EphrinB2
Renal fibrosis
Mitochondrial dynamics
Oxidative stress
Epac1-Rap1 signaling
Online Access:https://doi.org/10.1186/s12967-025-06852-1
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https://doi.org/10.1186/s12967-025-06852-1

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