Roles of human papillomavirus in cancers: oncogenic mechanisms and clinical use
Abstract Human papillomaviruses, particularly high-risk human papillomaviruses, have been universally considered to be associated with the oncogenesis and progression of various cancers. The genome of human papillomaviruses is circular, double-stranded DNA that encodes early and late proteins. Each...
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Nature Publishing Group
2025-01-01
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| Series: | Signal Transduction and Targeted Therapy |
| Online Access: | https://doi.org/10.1038/s41392-024-02083-w |
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| author | Yu Zhang Ke Qiu Jianjun Ren Yu Zhao Ping Cheng |
| author_facet | Yu Zhang Ke Qiu Jianjun Ren Yu Zhao Ping Cheng |
| author_sort | Yu Zhang |
| collection | DOAJ |
| description | Abstract Human papillomaviruses, particularly high-risk human papillomaviruses, have been universally considered to be associated with the oncogenesis and progression of various cancers. The genome of human papillomaviruses is circular, double-stranded DNA that encodes early and late proteins. Each of the proteins is of crucial significance in infecting the epithelium of host cells persistently and supporting viral genome integrating into host cells. Notably, E6 and E7 proteins, classified as oncoproteins, trigger the incidence of cancers by fostering cell proliferation, hindering apoptosis, evading immune surveillance, promoting cell invasion, and disrupting the balance of cellular metabolism. Therefore, targeting human papillomaviruses and decoding molecular mechanisms by which human papillomaviruses drive carcinogenesis are of great necessity to better treat human papillomaviruses-related cancers. Human papillomaviruses have been applied clinically to different facets of human papillomavirus-related cancers, including prevention, screening, diagnosis, treatment, and prognosis. Several types of prophylactic vaccines have been publicly utilized worldwide and have greatly decreased the occurrence of human papillomavirus-related cancers, which have benefited numerous people. Although various therapeutic vaccines have been developed and tested clinically, none of them have been officially approved to date. Enhancing the efficacy of vaccines and searching for innovative technologies targeting human papillomaviruses remain critical challenges that warrant continuous research and attention in the future. |
| format | Article |
| id | doaj-art-4df47e647ce34e399cc0c5d4a4e260c7 |
| institution | Kabale University |
| issn | 2059-3635 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
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| series | Signal Transduction and Targeted Therapy |
| spelling | doaj-art-4df47e647ce34e399cc0c5d4a4e260c72025-01-26T12:54:29ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352025-01-0110112210.1038/s41392-024-02083-wRoles of human papillomavirus in cancers: oncogenic mechanisms and clinical useYu Zhang0Ke Qiu1Jianjun Ren2Yu Zhao3Ping Cheng4Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityDepartment of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan UniversityDepartment of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan UniversityDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityAbstract Human papillomaviruses, particularly high-risk human papillomaviruses, have been universally considered to be associated with the oncogenesis and progression of various cancers. The genome of human papillomaviruses is circular, double-stranded DNA that encodes early and late proteins. Each of the proteins is of crucial significance in infecting the epithelium of host cells persistently and supporting viral genome integrating into host cells. Notably, E6 and E7 proteins, classified as oncoproteins, trigger the incidence of cancers by fostering cell proliferation, hindering apoptosis, evading immune surveillance, promoting cell invasion, and disrupting the balance of cellular metabolism. Therefore, targeting human papillomaviruses and decoding molecular mechanisms by which human papillomaviruses drive carcinogenesis are of great necessity to better treat human papillomaviruses-related cancers. Human papillomaviruses have been applied clinically to different facets of human papillomavirus-related cancers, including prevention, screening, diagnosis, treatment, and prognosis. Several types of prophylactic vaccines have been publicly utilized worldwide and have greatly decreased the occurrence of human papillomavirus-related cancers, which have benefited numerous people. Although various therapeutic vaccines have been developed and tested clinically, none of them have been officially approved to date. Enhancing the efficacy of vaccines and searching for innovative technologies targeting human papillomaviruses remain critical challenges that warrant continuous research and attention in the future.https://doi.org/10.1038/s41392-024-02083-w |
| spellingShingle | Yu Zhang Ke Qiu Jianjun Ren Yu Zhao Ping Cheng Roles of human papillomavirus in cancers: oncogenic mechanisms and clinical use Signal Transduction and Targeted Therapy |
| title | Roles of human papillomavirus in cancers: oncogenic mechanisms and clinical use |
| title_full | Roles of human papillomavirus in cancers: oncogenic mechanisms and clinical use |
| title_fullStr | Roles of human papillomavirus in cancers: oncogenic mechanisms and clinical use |
| title_full_unstemmed | Roles of human papillomavirus in cancers: oncogenic mechanisms and clinical use |
| title_short | Roles of human papillomavirus in cancers: oncogenic mechanisms and clinical use |
| title_sort | roles of human papillomavirus in cancers oncogenic mechanisms and clinical use |
| url | https://doi.org/10.1038/s41392-024-02083-w |
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