Rational Design, Synthesis and In Vitro Activity of Diastereomeric <i>Cis</i>-/<i>Trans</i>-3-Substituted-3,4-Dihydroisocoumarin-4-Carboxylic Acids as Potential Carnitine Acetyltransferase Inhibitors

Rational Design, Synthesis and In Vitro Activity of Diastereomeric <i>Cis</i>-/<i>Trans</i>-3-Substituted-3,4-Dihydroisocoumarin-4-Carboxylic Acids as Potential Carnitine Acetyltransferase Inhibitors

This study explores a series of 3,4-dihydroisocoumarins as potential inhibitors of fatty acid oxidation through rational design, synthesis and in vitro evaluation. The compounds studied were designed as structural analogs of the natural substrates of carnitine acetyltransferase (CAT) and other enzym...

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Bibliographic Details
Main Authors: Savina Stoyanova, Milen G. Bogdanov
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
carnitine acyltransferase
fatty acid oxidation
isocoumarins
metabolism
enzyme inhibition
Online Access:https://www.mdpi.com/1420-3049/30/15/3159
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