Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma
Intracranial undifferentiated pleomorphic sarcoma remains a rare pathology within the sarcoma literature that may arise primarily or secondary after radiation therapy. Despite first-line treatment with maximal surgical resection, followed by nonstandardized adjuvant chemotherapy/radiation regimens,...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Genetics |
| Online Access: | http://dx.doi.org/10.1155/2021/5586072 |
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| _version_ | 1832564884036911104 |
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| author | Christopher S. Hong Edwin Partovi James Clune Anita Huttner Henry S. Park Sacit Bulent Omay |
| author_facet | Christopher S. Hong Edwin Partovi James Clune Anita Huttner Henry S. Park Sacit Bulent Omay |
| author_sort | Christopher S. Hong |
| collection | DOAJ |
| description | Intracranial undifferentiated pleomorphic sarcoma remains a rare pathology within the sarcoma literature that may arise primarily or secondary after radiation therapy. Despite first-line treatment with maximal surgical resection, followed by nonstandardized adjuvant chemotherapy/radiation regimens, clinical prognosis remains exceedingly poor. Furthermore, there is a lack of genetic or molecular characterization to guide potential for targeted therapies. We present genomic analysis of a radiation-induced intracranial undifferentiated pleomorphic sarcoma in an 83-year-old woman with notable KIT and PDGFRA alterations. Further similar genomic studies of intracranial pleomorphic sarcoma are needed to develop better therapies for this rare but challenging disease entity. |
| format | Article |
| id | doaj-art-4de6ea74f76042b2a43df6fb2dd91f66 |
| institution | Kabale University |
| issn | 2090-6544 2090-6552 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Genetics |
| spelling | doaj-art-4de6ea74f76042b2a43df6fb2dd91f662025-02-03T01:09:56ZengWileyCase Reports in Genetics2090-65442090-65522021-01-01202110.1155/2021/55860725586072Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic SarcomaChristopher S. Hong0Edwin Partovi1James Clune2Anita Huttner3Henry S. Park4Sacit Bulent Omay5Department of Neurosurgery, Yale School of Medicine, New Haven 06511, CT, USADepartment of Pathology, Yale School of Medicine, New Haven 06511, CT, USADivision of Plastic and Reconstructive Surgery, Department of Surgery, Yale School of Medicine, New Haven 06511, CT, USADepartment of Pathology, Yale School of Medicine, New Haven 06511, CT, USADepartment of Therapeutic Radiology, Yale School of Medicine, New Haven 06511, CT, USADepartment of Neurosurgery, Yale School of Medicine, New Haven 06511, CT, USAIntracranial undifferentiated pleomorphic sarcoma remains a rare pathology within the sarcoma literature that may arise primarily or secondary after radiation therapy. Despite first-line treatment with maximal surgical resection, followed by nonstandardized adjuvant chemotherapy/radiation regimens, clinical prognosis remains exceedingly poor. Furthermore, there is a lack of genetic or molecular characterization to guide potential for targeted therapies. We present genomic analysis of a radiation-induced intracranial undifferentiated pleomorphic sarcoma in an 83-year-old woman with notable KIT and PDGFRA alterations. Further similar genomic studies of intracranial pleomorphic sarcoma are needed to develop better therapies for this rare but challenging disease entity.http://dx.doi.org/10.1155/2021/5586072 |
| spellingShingle | Christopher S. Hong Edwin Partovi James Clune Anita Huttner Henry S. Park Sacit Bulent Omay Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma Case Reports in Genetics |
| title | Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma |
| title_full | Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma |
| title_fullStr | Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma |
| title_full_unstemmed | Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma |
| title_short | Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma |
| title_sort | genomic characterization of radiation induced intracranial undifferentiated pleomorphic sarcoma |
| url | http://dx.doi.org/10.1155/2021/5586072 |
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