Autologous Graft-versus-Tumor Effect: Reality or Fiction?
In contrast to allogeneic hematopoietic stem cell transplantation, the current dogma is not an evidence of graft-versus-tumor effect in autologous hematopoietic stem cell transplantation; thus, it is assumed that autologous hematopoietic stem cell transplantation only relies on the high-dose chemoth...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2016/5385972 |
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| _version_ | 1832568426532438016 |
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| author | Luis F. Porrata |
| author_facet | Luis F. Porrata |
| author_sort | Luis F. Porrata |
| collection | DOAJ |
| description | In contrast to allogeneic hematopoietic stem cell transplantation, the current dogma is not an evidence of graft-versus-tumor effect in autologous hematopoietic stem cell transplantation; thus, it is assumed that autologous hematopoietic stem cell transplantation only relies on the high-dose chemotherapy to improve clinical outcomes. However, recent studies argue in favor of the existence of an autologous graft-versus-tumor without the detrimental complications of graft-versus-host disease due to the nonspecific immune response from the infused donor alloreactive immune effector cells in allogeneic hematopoietic stem cell transplantation. Herein, this paper reviews the clinical evidence of an autologous graft-versus-tumor effect based on the autograft collected and infused host immune effector cells and host immunity recovery after autologous hematopoietic stem cell transplantation affecting clinical outcomes in cancer patients. |
| format | Article |
| id | doaj-art-4de0cac6895c4747ad55cdfa962a4a9c |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-4de0cac6895c4747ad55cdfa962a4a9c2025-02-03T00:59:02ZengWileyAdvances in Hematology1687-91041687-91122016-01-01201610.1155/2016/53859725385972Autologous Graft-versus-Tumor Effect: Reality or Fiction?Luis F. Porrata0Division of Hematology, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USAIn contrast to allogeneic hematopoietic stem cell transplantation, the current dogma is not an evidence of graft-versus-tumor effect in autologous hematopoietic stem cell transplantation; thus, it is assumed that autologous hematopoietic stem cell transplantation only relies on the high-dose chemotherapy to improve clinical outcomes. However, recent studies argue in favor of the existence of an autologous graft-versus-tumor without the detrimental complications of graft-versus-host disease due to the nonspecific immune response from the infused donor alloreactive immune effector cells in allogeneic hematopoietic stem cell transplantation. Herein, this paper reviews the clinical evidence of an autologous graft-versus-tumor effect based on the autograft collected and infused host immune effector cells and host immunity recovery after autologous hematopoietic stem cell transplantation affecting clinical outcomes in cancer patients.http://dx.doi.org/10.1155/2016/5385972 |
| spellingShingle | Luis F. Porrata Autologous Graft-versus-Tumor Effect: Reality or Fiction? Advances in Hematology |
| title | Autologous Graft-versus-Tumor Effect: Reality or Fiction? |
| title_full | Autologous Graft-versus-Tumor Effect: Reality or Fiction? |
| title_fullStr | Autologous Graft-versus-Tumor Effect: Reality or Fiction? |
| title_full_unstemmed | Autologous Graft-versus-Tumor Effect: Reality or Fiction? |
| title_short | Autologous Graft-versus-Tumor Effect: Reality or Fiction? |
| title_sort | autologous graft versus tumor effect reality or fiction |
| url | http://dx.doi.org/10.1155/2016/5385972 |
| work_keys_str_mv | AT luisfporrata autologousgraftversustumoreffectrealityorfiction |