Systemic immune-inflammation index: Unveiling the diagnostic potential in ulcerative colitis through a comprehensive systematic review and meta-analysis
Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unpredictable colon and rectum inflammation episodes. Evaluating disease activity is essential for effective management. The systemic immune-inflammation index (SII) is a potential biomarker for assessing inflammation a...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2025-01-01
|
| Series: | Gastroenterology & Endoscopy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949752324000621 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594135200038912 |
|---|---|
| author | Anas Elgenidy Omar Alomari Tasbih Emad Sara K. Kamal Islam E. Al Ghanam Aya Sherif Mohammed Al-mahdi Al-kurdi Abdallah A. Helal Yusof Mohamed Omar Mohamed Rafiek Ramadan |
| author_facet | Anas Elgenidy Omar Alomari Tasbih Emad Sara K. Kamal Islam E. Al Ghanam Aya Sherif Mohammed Al-mahdi Al-kurdi Abdallah A. Helal Yusof Mohamed Omar Mohamed Rafiek Ramadan |
| author_sort | Anas Elgenidy |
| collection | DOAJ |
| description | Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unpredictable colon and rectum inflammation episodes. Evaluating disease activity is essential for effective management. The systemic immune-inflammation index (SII) is a potential biomarker for assessing inflammation and disease severity in UC. This meta-analysis aims to comprehensively assess the utility of SII in UC by analyzing its association with disease activity. Methods: PubMed, Scopus, Embase, Cochrane, and Web of Science databases have been searched for relevant studies OpenMetaAnalyst software were utilized in the analysis. Furthermore, we conducted a diagnostic test accuracy (DTA) analysis using Meta-Disc version 2.0 software, employing a univariate model to assess the sensitivity, specificity, and predictive value of SII. Results: We included seven retrospective studies comprising 1127 UC patients and 686 healthy controls. Our analysis revealed a significantly higher SII in UC patients compared to healthy controls (mean difference: −620.00, 95 % CI -1337.08 – 97.07), indicating its potential as a diagnostic marker. SII was also significantly lower in UC patients in remission compared to those with active disease (mean difference: −521.71, 95 % CI -962.92 to −80.50), suggesting its role in monitoring disease activity. The DTA analysis demonstrated a pooled sensitivity of 0.622 and specificity of 0.805 for SII in predicting UC activity, with a diagnostic odds ratio of 6.773. Conclusion: Our meta-analysis reveals that the SII holds significant promise as a non-invasive marker for assessing the activity and severity of UC. The findings demonstrate that SII is significantly lower in healthy controls compared to UC patients and lower in patients in remission compared to those with active disease. |
| format | Article |
| id | doaj-art-4dc84a9a061d4c52bc4ef360865ffb66 |
| institution | Kabale University |
| issn | 2949-7523 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Gastroenterology & Endoscopy |
| spelling | doaj-art-4dc84a9a061d4c52bc4ef360865ffb662025-01-20T04:18:06ZengKeAi Communications Co., Ltd.Gastroenterology & Endoscopy2949-75232025-01-01312231Systemic immune-inflammation index: Unveiling the diagnostic potential in ulcerative colitis through a comprehensive systematic review and meta-analysisAnas Elgenidy0Omar Alomari1Tasbih Emad2Sara K. Kamal3Islam E. Al Ghanam4Aya Sherif5Mohammed Al-mahdi Al-kurdi6Abdallah A. Helal7Yusof Mohamed Omar8Mohamed Rafiek Ramadan9Faculty of Medicine, Cairo University, Cairo, EgyptHamidiye International School of Medicine, University of Health Sciences, Istanbul, Turkey; Corresponding author. Hamidiye International School of Medicine, University of Health Sciences, Istanbul 34668, Turkey.Faculty of Physical Therapy, Cairo University, Cairo, EgyptFaculty of Medicine, Cairo University, Cairo, EgyptFaculty of Medicine, Ain Shams University, Cairo, EgyptFaculty of Medicine, Beni Suef University, Beni Suef, EgyptFaculty of Medicine, Aleppo University, Aleppo, SyriaFaculty of Medicine, Fayoum University, Fayoum, EgyptFaculty of Medicine, Mansoura University, Dakahlia, EgyptFaculty of Medicine, Tanta University, Tanta, EgyptBackground: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unpredictable colon and rectum inflammation episodes. Evaluating disease activity is essential for effective management. The systemic immune-inflammation index (SII) is a potential biomarker for assessing inflammation and disease severity in UC. This meta-analysis aims to comprehensively assess the utility of SII in UC by analyzing its association with disease activity. Methods: PubMed, Scopus, Embase, Cochrane, and Web of Science databases have been searched for relevant studies OpenMetaAnalyst software were utilized in the analysis. Furthermore, we conducted a diagnostic test accuracy (DTA) analysis using Meta-Disc version 2.0 software, employing a univariate model to assess the sensitivity, specificity, and predictive value of SII. Results: We included seven retrospective studies comprising 1127 UC patients and 686 healthy controls. Our analysis revealed a significantly higher SII in UC patients compared to healthy controls (mean difference: −620.00, 95 % CI -1337.08 – 97.07), indicating its potential as a diagnostic marker. SII was also significantly lower in UC patients in remission compared to those with active disease (mean difference: −521.71, 95 % CI -962.92 to −80.50), suggesting its role in monitoring disease activity. The DTA analysis demonstrated a pooled sensitivity of 0.622 and specificity of 0.805 for SII in predicting UC activity, with a diagnostic odds ratio of 6.773. Conclusion: Our meta-analysis reveals that the SII holds significant promise as a non-invasive marker for assessing the activity and severity of UC. The findings demonstrate that SII is significantly lower in healthy controls compared to UC patients and lower in patients in remission compared to those with active disease.http://www.sciencedirect.com/science/article/pii/S2949752324000621Ulcerative colitisDiagnosisSIIDisease severityDTA |
| spellingShingle | Anas Elgenidy Omar Alomari Tasbih Emad Sara K. Kamal Islam E. Al Ghanam Aya Sherif Mohammed Al-mahdi Al-kurdi Abdallah A. Helal Yusof Mohamed Omar Mohamed Rafiek Ramadan Systemic immune-inflammation index: Unveiling the diagnostic potential in ulcerative colitis through a comprehensive systematic review and meta-analysis Gastroenterology & Endoscopy Ulcerative colitis Diagnosis SII Disease severity DTA |
| title | Systemic immune-inflammation index: Unveiling the diagnostic potential in ulcerative colitis through a comprehensive systematic review and meta-analysis |
| title_full | Systemic immune-inflammation index: Unveiling the diagnostic potential in ulcerative colitis through a comprehensive systematic review and meta-analysis |
| title_fullStr | Systemic immune-inflammation index: Unveiling the diagnostic potential in ulcerative colitis through a comprehensive systematic review and meta-analysis |
| title_full_unstemmed | Systemic immune-inflammation index: Unveiling the diagnostic potential in ulcerative colitis through a comprehensive systematic review and meta-analysis |
| title_short | Systemic immune-inflammation index: Unveiling the diagnostic potential in ulcerative colitis through a comprehensive systematic review and meta-analysis |
| title_sort | systemic immune inflammation index unveiling the diagnostic potential in ulcerative colitis through a comprehensive systematic review and meta analysis |
| topic | Ulcerative colitis Diagnosis SII Disease severity DTA |
| url | http://www.sciencedirect.com/science/article/pii/S2949752324000621 |
| work_keys_str_mv | AT anaselgenidy systemicimmuneinflammationindexunveilingthediagnosticpotentialinulcerativecolitisthroughacomprehensivesystematicreviewandmetaanalysis AT omaralomari systemicimmuneinflammationindexunveilingthediagnosticpotentialinulcerativecolitisthroughacomprehensivesystematicreviewandmetaanalysis AT tasbihemad systemicimmuneinflammationindexunveilingthediagnosticpotentialinulcerativecolitisthroughacomprehensivesystematicreviewandmetaanalysis AT sarakkamal systemicimmuneinflammationindexunveilingthediagnosticpotentialinulcerativecolitisthroughacomprehensivesystematicreviewandmetaanalysis AT islamealghanam systemicimmuneinflammationindexunveilingthediagnosticpotentialinulcerativecolitisthroughacomprehensivesystematicreviewandmetaanalysis AT ayasherif systemicimmuneinflammationindexunveilingthediagnosticpotentialinulcerativecolitisthroughacomprehensivesystematicreviewandmetaanalysis AT mohammedalmahdialkurdi systemicimmuneinflammationindexunveilingthediagnosticpotentialinulcerativecolitisthroughacomprehensivesystematicreviewandmetaanalysis AT abdallahahelal systemicimmuneinflammationindexunveilingthediagnosticpotentialinulcerativecolitisthroughacomprehensivesystematicreviewandmetaanalysis AT yusofmohamedomar systemicimmuneinflammationindexunveilingthediagnosticpotentialinulcerativecolitisthroughacomprehensivesystematicreviewandmetaanalysis AT mohamedrafiekramadan systemicimmuneinflammationindexunveilingthediagnosticpotentialinulcerativecolitisthroughacomprehensivesystematicreviewandmetaanalysis |