Development of Multi-Phase Solid Formation for Dissolution Enhancement of Higher Drug Loading Phase-Separated Melt
The method of Multi-Phase Solid with Shear (MPSwS), which uses shear force to form multi-phase solids, was investigated to evaluate the effect of changing drug loadings on the dissolution performance of API. Dissolution results showed that the dissolution rate monotonically decreased when the drug l...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Chemical Engineering of Japan |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/00219592.2025.2461078 |
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| author | Bolor-Uyanga Tumurbaatar Hiroshi Takiyama |
| author_facet | Bolor-Uyanga Tumurbaatar Hiroshi Takiyama |
| author_sort | Bolor-Uyanga Tumurbaatar |
| collection | DOAJ |
| description | The method of Multi-Phase Solid with Shear (MPSwS), which uses shear force to form multi-phase solids, was investigated to evaluate the effect of changing drug loadings on the dissolution performance of API. Dissolution results showed that the dissolution rate monotonically decreased when the drug loading exceeded a certain amount. Therefore, a novel method was proposed to upgrade the MPSwS method and enhance the dissolution performance even with higher drug loading. The novel MPSwS&A method, which combined shear force and aeration, was used to form the pore structure in the solid. Dissolution results showed that the novel MPSwS&A method enhanced the dissolution rate. From the fractured surface of the solid, the pore structure caused by bubbles and the structure formed by fine crystalline particles were observed. These results suggest that the combination of shear force and aeration enhances API dissolution performance by the synergistic effects of forming micro and macro structures. |
| format | Article |
| id | doaj-art-4da58c69ad784454956ebb6ddcdeacc8 |
| institution | Kabale University |
| issn | 0021-9592 1881-1299 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Chemical Engineering of Japan |
| spelling | doaj-art-4da58c69ad784454956ebb6ddcdeacc82025-02-05T16:24:28ZengTaylor & Francis GroupJournal of Chemical Engineering of Japan0021-95921881-12992025-12-0158110.1080/00219592.2025.2461078Development of Multi-Phase Solid Formation for Dissolution Enhancement of Higher Drug Loading Phase-Separated MeltBolor-Uyanga Tumurbaatar0Hiroshi Takiyama1Department of Chemical Engineering, Tokyo University of Agriculture and Technology, Koganei-shi, JapanDepartment of Chemical Engineering, Tokyo University of Agriculture and Technology, Koganei-shi, JapanThe method of Multi-Phase Solid with Shear (MPSwS), which uses shear force to form multi-phase solids, was investigated to evaluate the effect of changing drug loadings on the dissolution performance of API. Dissolution results showed that the dissolution rate monotonically decreased when the drug loading exceeded a certain amount. Therefore, a novel method was proposed to upgrade the MPSwS method and enhance the dissolution performance even with higher drug loading. The novel MPSwS&A method, which combined shear force and aeration, was used to form the pore structure in the solid. Dissolution results showed that the novel MPSwS&A method enhanced the dissolution rate. From the fractured surface of the solid, the pore structure caused by bubbles and the structure formed by fine crystalline particles were observed. These results suggest that the combination of shear force and aeration enhances API dissolution performance by the synergistic effects of forming micro and macro structures.https://www.tandfonline.com/doi/10.1080/00219592.2025.2461078Melt crystallizationMulti-phase solidDissolution performanceShear forceAeration |
| spellingShingle | Bolor-Uyanga Tumurbaatar Hiroshi Takiyama Development of Multi-Phase Solid Formation for Dissolution Enhancement of Higher Drug Loading Phase-Separated Melt Journal of Chemical Engineering of Japan Melt crystallization Multi-phase solid Dissolution performance Shear force Aeration |
| title | Development of Multi-Phase Solid Formation for Dissolution Enhancement of Higher Drug Loading Phase-Separated Melt |
| title_full | Development of Multi-Phase Solid Formation for Dissolution Enhancement of Higher Drug Loading Phase-Separated Melt |
| title_fullStr | Development of Multi-Phase Solid Formation for Dissolution Enhancement of Higher Drug Loading Phase-Separated Melt |
| title_full_unstemmed | Development of Multi-Phase Solid Formation for Dissolution Enhancement of Higher Drug Loading Phase-Separated Melt |
| title_short | Development of Multi-Phase Solid Formation for Dissolution Enhancement of Higher Drug Loading Phase-Separated Melt |
| title_sort | development of multi phase solid formation for dissolution enhancement of higher drug loading phase separated melt |
| topic | Melt crystallization Multi-phase solid Dissolution performance Shear force Aeration |
| url | https://www.tandfonline.com/doi/10.1080/00219592.2025.2461078 |
| work_keys_str_mv | AT boloruyangatumurbaatar developmentofmultiphasesolidformationfordissolutionenhancementofhigherdrugloadingphaseseparatedmelt AT hiroshitakiyama developmentofmultiphasesolidformationfordissolutionenhancementofhigherdrugloadingphaseseparatedmelt |