68Ga-Pentixafor PET/CT for the assessment of therapeutic outcomes following superselective adrenal arterial embolization in patients with primary aldosteronism
Abstract Background Superselective adrenal artery embolization (SAAE) represents a novel therapeutic strategy for managing primary aldosteronism (PA). Currently, the evaluation of its efficacy is primarily restricted to clinical indicators, with a notable deficiency in imaging evaluation methodologi...
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2025-01-01
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| Series: | EJNMMI Research |
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| Online Access: | https://doi.org/10.1186/s13550-024-01194-3 |
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| author | MengDan Li Lili Guan Lu Yang WenBo Li Zhu Xia Min Mao Hua Pang |
| author_facet | MengDan Li Lili Guan Lu Yang WenBo Li Zhu Xia Min Mao Hua Pang |
| author_sort | MengDan Li |
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| description | Abstract Background Superselective adrenal artery embolization (SAAE) represents a novel therapeutic strategy for managing primary aldosteronism (PA). Currently, the evaluation of its efficacy is primarily restricted to clinical indicators, with a notable deficiency in imaging evaluation methodologies. In recent years, several studies have investigated the application of 68Ga-Pentixafor PET/CT for the classification of PA. However, there is a scarcity of specific research investigating the role of PET/CT in the evaluation of efficacy of this condition. Consequently, this study aims to evaluate the therapeutic efficacy of SAAE in patients with PA using 68Ga-Pentixafor PET/CT, with the objective of establishing imaging evaluation methodologies for assessing PA patients post-SAAE treatment. Results Of the 27 patients, 2 achieved complete clinical remission, while 25 experienced partial remission. Biochemically, 13 patients attained complete remission, 13 had partial remission, and 1 did not. For patients with aldosterone-producing adenoma, both visual and semi-quantitative analyses of PET/CT effectively assessed changes in radioactive uptake of the lesion. For idiopathic hyperaldosteronism patients, PET/CT parameters were more effective than visual analysis in evaluating SAAE efficacy. A significant difference in the ΔTLR-40 min parameter was observed across biochemical outcomes (P = 0.041), with patients having ΔTLR-40 min ≥ 0.07 showing better outcomes (AUC = 0.789, P = 0.041). Conclusions 68Ga-Pentixafor PET/CT enables timely assessment of therapeutic outcomes in patients with PA following SAAE, thereby improving clinical decision-making and patient management. |
| format | Article |
| id | doaj-art-4d9d0d03aeef4a56a3502bf5b71ba757 |
| institution | Kabale University |
| issn | 2191-219X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
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| series | EJNMMI Research |
| spelling | doaj-art-4d9d0d03aeef4a56a3502bf5b71ba7572025-01-19T12:38:23ZengSpringerOpenEJNMMI Research2191-219X2025-01-0115111110.1186/s13550-024-01194-368Ga-Pentixafor PET/CT for the assessment of therapeutic outcomes following superselective adrenal arterial embolization in patients with primary aldosteronismMengDan Li0Lili Guan1Lu Yang2WenBo Li3Zhu Xia4Min Mao5Hua Pang6Department of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical UniversityAbstract Background Superselective adrenal artery embolization (SAAE) represents a novel therapeutic strategy for managing primary aldosteronism (PA). Currently, the evaluation of its efficacy is primarily restricted to clinical indicators, with a notable deficiency in imaging evaluation methodologies. In recent years, several studies have investigated the application of 68Ga-Pentixafor PET/CT for the classification of PA. However, there is a scarcity of specific research investigating the role of PET/CT in the evaluation of efficacy of this condition. Consequently, this study aims to evaluate the therapeutic efficacy of SAAE in patients with PA using 68Ga-Pentixafor PET/CT, with the objective of establishing imaging evaluation methodologies for assessing PA patients post-SAAE treatment. Results Of the 27 patients, 2 achieved complete clinical remission, while 25 experienced partial remission. Biochemically, 13 patients attained complete remission, 13 had partial remission, and 1 did not. For patients with aldosterone-producing adenoma, both visual and semi-quantitative analyses of PET/CT effectively assessed changes in radioactive uptake of the lesion. For idiopathic hyperaldosteronism patients, PET/CT parameters were more effective than visual analysis in evaluating SAAE efficacy. A significant difference in the ΔTLR-40 min parameter was observed across biochemical outcomes (P = 0.041), with patients having ΔTLR-40 min ≥ 0.07 showing better outcomes (AUC = 0.789, P = 0.041). Conclusions 68Ga-Pentixafor PET/CT enables timely assessment of therapeutic outcomes in patients with PA following SAAE, thereby improving clinical decision-making and patient management.https://doi.org/10.1186/s13550-024-01194-3Primary aldosteronism68Ga-PentixaforPET/CTSuperselective adrenal arterial embolization |
| spellingShingle | MengDan Li Lili Guan Lu Yang WenBo Li Zhu Xia Min Mao Hua Pang 68Ga-Pentixafor PET/CT for the assessment of therapeutic outcomes following superselective adrenal arterial embolization in patients with primary aldosteronism EJNMMI Research Primary aldosteronism 68Ga-Pentixafor PET/CT Superselective adrenal arterial embolization |
| title | 68Ga-Pentixafor PET/CT for the assessment of therapeutic outcomes following superselective adrenal arterial embolization in patients with primary aldosteronism |
| title_full | 68Ga-Pentixafor PET/CT for the assessment of therapeutic outcomes following superselective adrenal arterial embolization in patients with primary aldosteronism |
| title_fullStr | 68Ga-Pentixafor PET/CT for the assessment of therapeutic outcomes following superselective adrenal arterial embolization in patients with primary aldosteronism |
| title_full_unstemmed | 68Ga-Pentixafor PET/CT for the assessment of therapeutic outcomes following superselective adrenal arterial embolization in patients with primary aldosteronism |
| title_short | 68Ga-Pentixafor PET/CT for the assessment of therapeutic outcomes following superselective adrenal arterial embolization in patients with primary aldosteronism |
| title_sort | 68ga pentixafor pet ct for the assessment of therapeutic outcomes following superselective adrenal arterial embolization in patients with primary aldosteronism |
| topic | Primary aldosteronism 68Ga-Pentixafor PET/CT Superselective adrenal arterial embolization |
| url | https://doi.org/10.1186/s13550-024-01194-3 |
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