Exosomal miRNAs involvement in pathogenesis, diagnosis, and treatment of rheumatoid arthritis
Rheumatoid arthritis (RA) is the most common chronic autoimmune arthropathy worldwide. The initiation, and progression of RA involves multiple cellular and molecular pathways, and biological interactions. Micro RNAs (miRNAs) are characterized as a class of small non-coding RNAs that influence gene e...
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Elsevier
2025-01-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025003639 |
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| author | Mahvash Sadeghi Jalil Tavakol Afshari Afsane Fadaee Mohammadreza Dashti Fatemeh Kheradmand Sajad Dehnavi Mojgan Mohammadi |
| author_facet | Mahvash Sadeghi Jalil Tavakol Afshari Afsane Fadaee Mohammadreza Dashti Fatemeh Kheradmand Sajad Dehnavi Mojgan Mohammadi |
| author_sort | Mahvash Sadeghi |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is the most common chronic autoimmune arthropathy worldwide. The initiation, and progression of RA involves multiple cellular and molecular pathways, and biological interactions. Micro RNAs (miRNAs) are characterized as a class of small non-coding RNAs that influence gene expression at the post-transcriptional level. Exosomes are biological nano-vesicles that are secreted by different types of cells. They facilitate communication and signalling between cells by transferring a variety of biological substances, such as proteins, lipids, and nucleic acids like mRNA and miRNA. Exosomal miRNAs were shown to be involved in normal and pathological conditions. In RA, deregulated exosomal miRNA expression was observed to be involved in the intercellular communication between synovial cells, and inflammatory or regulatory immune cells. Furthermore, circulating exosomal miRNAs were introduced as available diagnostic and prognostic biomarkers for RA pathology. The current review categorized and summarized dysregulated pathologically involved and circulating exosomal miRNAs in the context of RA. It highlighted present situation and future perspective of using exosomal miRNAs as biomarkers and a specific gene therapy approach for RA treatment. |
| format | Article |
| id | doaj-art-4d824ca13c7244828db26dd36172dc8e |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-4d824ca13c7244828db26dd36172dc8e2025-02-02T05:28:42ZengElsevierHeliyon2405-84402025-01-01112e41983Exosomal miRNAs involvement in pathogenesis, diagnosis, and treatment of rheumatoid arthritisMahvash Sadeghi0Jalil Tavakol Afshari1Afsane Fadaee2Mohammadreza Dashti3Fatemeh Kheradmand4Sajad Dehnavi5Mojgan Mohammadi6Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, IranImmunology Research Center, Mashhad University of Medical Sciences, Mashhad, IranImmunology Research Center, Mashhad University of Medical Sciences, Mashhad, IranKashmar School of Medical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran; Student Research Committee, Mashhad University of Medical Sciences, Mashhad, IranImmunology Research Center, Mashhad University of Medical Sciences, Mashhad, IranAllergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Corresponding author. Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.dehnavis@mums.ac.irPharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran; Corresponding author.mohammadimzh@mums.ac.irRheumatoid arthritis (RA) is the most common chronic autoimmune arthropathy worldwide. The initiation, and progression of RA involves multiple cellular and molecular pathways, and biological interactions. Micro RNAs (miRNAs) are characterized as a class of small non-coding RNAs that influence gene expression at the post-transcriptional level. Exosomes are biological nano-vesicles that are secreted by different types of cells. They facilitate communication and signalling between cells by transferring a variety of biological substances, such as proteins, lipids, and nucleic acids like mRNA and miRNA. Exosomal miRNAs were shown to be involved in normal and pathological conditions. In RA, deregulated exosomal miRNA expression was observed to be involved in the intercellular communication between synovial cells, and inflammatory or regulatory immune cells. Furthermore, circulating exosomal miRNAs were introduced as available diagnostic and prognostic biomarkers for RA pathology. The current review categorized and summarized dysregulated pathologically involved and circulating exosomal miRNAs in the context of RA. It highlighted present situation and future perspective of using exosomal miRNAs as biomarkers and a specific gene therapy approach for RA treatment.http://www.sciencedirect.com/science/article/pii/S2405844025003639Rheumatoid arthritisExosomemiRNAExosomal miRNA |
| spellingShingle | Mahvash Sadeghi Jalil Tavakol Afshari Afsane Fadaee Mohammadreza Dashti Fatemeh Kheradmand Sajad Dehnavi Mojgan Mohammadi Exosomal miRNAs involvement in pathogenesis, diagnosis, and treatment of rheumatoid arthritis Heliyon Rheumatoid arthritis Exosome miRNA Exosomal miRNA |
| title | Exosomal miRNAs involvement in pathogenesis, diagnosis, and treatment of rheumatoid arthritis |
| title_full | Exosomal miRNAs involvement in pathogenesis, diagnosis, and treatment of rheumatoid arthritis |
| title_fullStr | Exosomal miRNAs involvement in pathogenesis, diagnosis, and treatment of rheumatoid arthritis |
| title_full_unstemmed | Exosomal miRNAs involvement in pathogenesis, diagnosis, and treatment of rheumatoid arthritis |
| title_short | Exosomal miRNAs involvement in pathogenesis, diagnosis, and treatment of rheumatoid arthritis |
| title_sort | exosomal mirnas involvement in pathogenesis diagnosis and treatment of rheumatoid arthritis |
| topic | Rheumatoid arthritis Exosome miRNA Exosomal miRNA |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025003639 |
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