Effects of a flavonoid-enriched orange peel extract against type 2 diabetes in the obese ZDF rat model
Effects of an enriched orange peel extract (OPE) against type 2 diabetes (T2D) were analyzed in ZDF rats which were hyperglycemic, dyslipidemic and express pro-inflammatory markers. Glucose related parameters were lowered in the lean control and metformin group as compared to ZDF vehicle controls. O...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2018-12-01
|
| Series: | Food Science and Human Wellness |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453018300934 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Effects of an enriched orange peel extract (OPE) against type 2 diabetes (T2D) were analyzed in ZDF rats which were hyperglycemic, dyslipidemic and express pro-inflammatory markers. Glucose related parameters were lowered in the lean control and metformin group as compared to ZDF vehicle controls. OPE was well tolerated and induced a decline in fasted blood glucose and increase levels of fed glucose although to a lesser degree as compared to metformin. However, OPE did not improve glucose tolerance but showed significantly elevated glucose levels. Furthermore, OPE treatment caused an increase of free fatty acids in a dose-responsive manner as well as elevated levels of cholesterol and LDL. The analysis of inflammatory mediators revealed a significant down-regulation of COX-2, ICAM-1, and TNF-α in epididymal adipose tissue in response to OPE to a higher degree as compared to ibuprofen. In whole blood, IL-4 was upregulated in a dose-responsive manner as measured by ELISA. In summary, lipophilic OPE showed strong anti-inflammatory effects in adipose tissue, ambivalent effects against hyperglycemia, whereas hyperlipidemia was increased. Our study emphasize the complexity of anti-diabetic regimen suggesting a treatment with OPE to reduce inflammation in adipose tissue in combination with antidiabetic therapeutics as promising strategy against T2D. Keywords: Type 2 diabetes, Orange peel, Zucker diabetic fatty rats, Chronic inflammation, Obesity |
|---|---|
| ISSN: | 2213-4530 |